Review
doi: 10.1016/S0140-6736(07)60601-1.
Autosomal dominant polycystic kidney disease
Affiliations
- PMID: 17434405
- DOI: 10.1016/S0140-6736(07)60601-1
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Review
Autosomal dominant polycystic kidney disease
Lancet.
.
Abstract
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments.
Comment in
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Early manifestations of polycystic kidney disease.Lancet. 2007 Jun 30;369(9580):2157. doi: 10.1016/S0140-6736(07)61005-8. Lancet. 2007. PMID: 17604790 No abstract available.
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