Structure and function of ABC transporters
- PMID: 17420303
- DOI: 10.1152/physiol.00046.2006
Structure and function of ABC transporters
Abstract
ATP binding cassette transporters are ubiquitous integral membrane proteins that actively transport ligands across biological membranes, a process critical for most aspects of cell physiology. These proteins are important clinically and economically. Their dysfunction underlies a number of human genetic diseases, and the ability of some to pump cytotoxic molecules from cells confers resistance to antibiotics, herbicides, and chemotherapeutic drugs. Recent structure analyses interpreted in light of a large body of biochemistry has resulted in the ATP-switch model for function in which the paired nucleotide binding domains switch between an ATP-dependent closed conformation and a nucleotide-free, open conformation to drive the translocation of ligand.
Similar articles
-
Structure and function of ABC transporters: the ATP switch provides flexible control.Pflugers Arch. 2007 Feb;453(5):555-67. doi: 10.1007/s00424-006-0126-x. Epub 2006 Aug 26. Pflugers Arch. 2007. PMID: 16937116 Review.
-
The ABC transporter structure and mechanism: perspectives on recent research.Cell Mol Life Sci. 2004 Mar;61(6):682-99. doi: 10.1007/s00018-003-3336-9. Cell Mol Life Sci. 2004. PMID: 15052411 Free PMC article. Review.
-
Mechanism of ABC transporters: a molecular dynamics simulation of a well characterized nucleotide-binding subunit.Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12639-44. doi: 10.1073/pnas.152439599. Epub 2002 Sep 17. Proc Natl Acad Sci U S A. 2002. PMID: 12237398 Free PMC article.
-
The ATP switch model for ABC transporters.Nat Struct Mol Biol. 2004 Oct;11(10):918-26. doi: 10.1038/nsmb836. Nat Struct Mol Biol. 2004. PMID: 15452563 Review.
-
ABC transporters: how small machines do a big job.Trends Microbiol. 2007 Oct;15(10):448-55. doi: 10.1016/j.tim.2007.09.005. Epub 2007 Oct 24. Trends Microbiol. 2007. PMID: 17920277 Review.
Cited by
-
Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes.Reproduction. 2022 Dec 2;165(1):79-91. doi: 10.1530/REP-22-0192. Print 2023 Jan 1. Reproduction. 2022. PMID: 36215093 Free PMC article.
-
ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.PLoS One. 2015 Jun 8;10(6):e0129772. doi: 10.1371/journal.pone.0129772. eCollection 2015. PLoS One. 2015. PMID: 26053025 Free PMC article.
-
KRAS and EGFR Mutations Differentially Alter ABC Drug Transporter Expression in Cisplatin-Resistant Non-Small Cell Lung Cancer.Int J Mol Sci. 2021 May 20;22(10):5384. doi: 10.3390/ijms22105384. Int J Mol Sci. 2021. PMID: 34065402 Free PMC article.
-
Reversible domain closure modulates GlnBP ligand binding affinity.PLoS One. 2022 Apr 21;17(4):e0263102. doi: 10.1371/journal.pone.0263102. eCollection 2022. PLoS One. 2022. PMID: 35446849 Free PMC article.
-
ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels.J Biol Chem. 2019 Mar 8;294(10):3707-3719. doi: 10.1074/jbc.RA118.005236. Epub 2018 Dec 26. J Biol Chem. 2019. PMID: 30587573 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
