Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies
- PMID: 17403720
- DOI: 10.1093/eurheartj/ehm026
Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies
Abstract
Aims: The objectives of this study were to determine the association of waist circumference (WC) and waist-to-hip ratio (WHR) with the risk of incident cardiovascular disease (CVD) events and to determine whether the strength of association of WC and WHR with CVD risk is different.
Methods and results: This meta-regression analysis used a search strategy of keywords and MeSH terms to identify prospective cohort studies and randomized clinical trials of CVD risk and abdominal obesity from the Medline, Embase, and Cochrane databases. Fifteen articles (n = 258 114 participants, 4355 CVD events) reporting CVD risk by categorical and continuous measures of WC and WHR were included. For a 1 cm increase in WC, the relative risk (RR) of a CVD event increased by 2% (95% CI: 1-3%) overall after adjusting for age, cohort year, or treatment. For a 0.01 U increase in WHR, the RR increased by 5% (95% CI: 4-7%). These results were consistent in men and women. Overall risk estimates comparing the extreme quantiles of each measure suggested that WHR was more strongly associated with CVD than that for WC (WHR: RR = 1.95, 95% CI: 1.55-2.44; WC: RR = 1.63, 95% CI: 1.31-2.04), although this difference was not significant. The strength of association for each measure was similar in men and women.
Conclusion: WHR and WC are significantly associated with the risk of incident CVD events. These simple measures of abdominal obesity should be incorporated into CVD risk assessments.
Comment in
-
Review: increased waist circumference or waist-to-hip ratio is associated with increased risk of cardiovascular events.Evid Based Med. 2007 Dec;12(6):184. doi: 10.1136/ebm.12.6.184. Evid Based Med. 2007. PMID: 18063744 No abstract available.
Similar articles
-
Hypertriglyceridemic waist and 7.5-year prospective risk of cardiovascular disease in asymptomatic middle-aged men.Int J Obes (Lond). 2007 May;31(5):791-6. doi: 10.1038/sj.ijo.0803477. Epub 2006 Oct 17. Int J Obes (Lond). 2007. PMID: 17047639 Clinical Trial.
-
Waist circumference cut-off points for identification of abdominal obesity among the tunisian adult population.Diabetes Obes Metab. 2007 Nov;9(6):859-68. doi: 10.1111/j.1463-1326.2006.00667.x. Diabetes Obes Metab. 2007. PMID: 17924868
-
Waist circumference and BMI cut-off based on 10-year cardiovascular risk: evidence for "central pre-obesity".Obesity (Silver Spring). 2007 Nov;15(11):2832-9. doi: 10.1038/oby.2007.336. Obesity (Silver Spring). 2007. PMID: 18070775
-
Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events.Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2533-47. doi: 10.1158/1055-9965.EPI-07-0708. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 18086756 Review.
-
Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis.Epidemiol Rev. 2007;29:115-28. doi: 10.1093/epirev/mxm008. Epub 2007 May 10. Epidemiol Rev. 2007. PMID: 17494056 Review.
Cited by
-
Muscle Mass Adjusted by Body Height is not Correlated with Mobility of Middle-Aged and Older Adults.Curr Dev Nutr. 2024 Jul 1;8(8):104412. doi: 10.1016/j.cdnut.2024.104412. eCollection 2024 Aug. Curr Dev Nutr. 2024. PMID: 39157007 Free PMC article.
-
The association between anthropometric indices and ischemic heart disease: a large-scale cross-sectional study on the Iranian population.Sci Rep. 2024 Aug 15;14(1):18950. doi: 10.1038/s41598-024-54148-z. Sci Rep. 2024. PMID: 39147775 Free PMC article.
-
Examining Generalizability across Different Surveys: Comparing Nutrient-Based Food Patterns and Their Cross-Sectional Associations with Cardiometabolic Health in the United States Hispanic/Latino Adults.Curr Dev Nutr. 2024 Jun 15;8(7):103797. doi: 10.1016/j.cdnut.2024.103797. eCollection 2024 Jul. Curr Dev Nutr. 2024. PMID: 39104805 Free PMC article.
-
Identification and verification of immune-related genes for diagnosing the progression of atherosclerosis and metabolic syndrome.BMC Cardiovasc Disord. 2024 Aug 2;24(1):405. doi: 10.1186/s12872-024-04026-3. BMC Cardiovasc Disord. 2024. PMID: 39095691 Free PMC article.
-
Impact of Obesity on Target Organ Damage in Patients with Metabolic Syndrome.Diagnostics (Basel). 2024 Jul 19;14(14):1569. doi: 10.3390/diagnostics14141569. Diagnostics (Basel). 2024. PMID: 39061706 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources