GI epidemiology: nonalcoholic fatty liver disease
- PMID: 17402991
- DOI: 10.1111/j.1365-2036.2007.03246.x
GI epidemiology: nonalcoholic fatty liver disease
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression.
Aim: To review the data available on the epidemiology and natural history of NAFLD as well as the risk factors for its development and the areas where future research is necessary. RESULTS /CONCLUSIONS: NAFLD may affect individuals of any age range and race/ethnicity. NAFLD affects one in three adults and one in ten children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications being a common cause of death. Liver-related morbidity and mortality in NAFLD occurs when the disease has progressed to advanced fibrosis and cirrhosis. Further studies are necessary to determine the impact of NAFLD on health-related quality of life and resources utilization, and to the extent to which preventing the development of the metabolic syndrome would prevent NAFLD development and reduce liver-related morbidity and mortality. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.
Similar articles
-
Obesity and nonalcoholic fatty liver disease.Nutr Rev. 2007 Jun;65(6 Pt 2):S57-63. doi: 10.1111/j.1753-4887.2007.tb00329.x. Nutr Rev. 2007. PMID: 17605315 Review.
-
The epidemiology of nonalcoholic fatty liver disease in adults.J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S5-10. doi: 10.1097/01.mcg.0000168638.84840.ff. J Clin Gastroenterol. 2006. PMID: 16540768 Review.
-
Nonalcoholic fatty liver disease.Ann Epidemiol. 2007 Nov;17(11):863-9. doi: 10.1016/j.annepidem.2007.05.013. Epub 2007 Aug 28. Ann Epidemiol. 2007. PMID: 17728149 Review.
-
Epidemiology of non-alcoholic fatty liver disease.Dig Dis. 2010;28(1):155-61. doi: 10.1159/000282080. Epub 2010 May 7. Dig Dis. 2010. PMID: 20460905
-
Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee.J Pediatr Gastroenterol Nutr. 2012 May;54(5):700-13. doi: 10.1097/MPG.0b013e318252a13f. J Pediatr Gastroenterol Nutr. 2012. PMID: 22395188
Cited by
-
Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study.Arch Med Sci. 2013 Jun 20;9(3):418-26. doi: 10.5114/aoms.2013.35424. Epub 2013 May 28. Arch Med Sci. 2013. PMID: 23847661 Free PMC article.
-
Prevalence and factors associated with nonalcoholic fatty liver disease in Shanghai work-units.BMC Gastroenterol. 2012 Sep 14;12:123. doi: 10.1186/1471-230X-12-123. BMC Gastroenterol. 2012. PMID: 22978800 Free PMC article.
-
Diagnosis and management of non-alcoholic fatty liver disease and related metabolic disorders: consensus statement from the Study Group of Liver and Metabolism, Chinese Society of Endocrinology.J Diabetes. 2013 Dec;5(4):406-15. doi: 10.1111/1753-0407.12056. Epub 2013 Jun 4. J Diabetes. 2013. PMID: 23560695 Free PMC article. Review.
-
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.Int J Mol Sci. 2016 Aug 23;17(9):1379. doi: 10.3390/ijms17091379. Int J Mol Sci. 2016. PMID: 27563875 Free PMC article. Review.
-
Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model.Front Microbiol. 2022 Mar 30;13:834776. doi: 10.3389/fmicb.2022.834776. eCollection 2022. Front Microbiol. 2022. PMID: 35432282 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical