Triggering the innate antiviral response through IRF-3 activation
- PMID: 17395583
- DOI: 10.1074/jbc.R700002200
Triggering the innate antiviral response through IRF-3 activation
Abstract
Rapid induction of type I interferon (IFN) expression is a central event in the establishment of the innate immune response against viral infection and requires the activation of multiple transcriptional proteins following engagement and signaling through Toll-like receptor-dependent and -independent pathways. The transcription factor interferon regulatory factor-3 (IRF-3) contributes to a first line of defense against viral infection by inducing the production of IFN-beta that in turn amplifies the IFN response and the development of antiviral activity. In murine knock-out models, the absence of IRF-3 and the closely related IRF-7 ablates IFN production and increases viral pathogenesis, thus supporting a pivotal role for IRF-3/IRF-7 in the development of the host antiviral response.
Similar articles
-
IRF-7 is the master regulator of type-I interferon-dependent immune responses.Nature. 2005 Apr 7;434(7034):772-7. doi: 10.1038/nature03464. Epub 2005 Mar 30. Nature. 2005. PMID: 15800576
-
Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7.J Immunol. 2007 Feb 15;178(4):2429-39. doi: 10.4049/jimmunol.178.4.2429. J Immunol. 2007. PMID: 17277150
-
Negative regulation of TBK1-mediated antiviral immunity.FEBS Lett. 2013 Mar 18;587(6):542-8. doi: 10.1016/j.febslet.2013.01.052. Epub 2013 Feb 8. FEBS Lett. 2013. PMID: 23395611 Free PMC article. Review.
-
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.J Virol. 2004 Oct;78(19):10636-49. doi: 10.1128/JVI.78.19.10636-10649.2004. J Virol. 2004. PMID: 15367631 Free PMC article.
-
The Role of Optineurin in Antiviral Type I Interferon Production.Front Immunol. 2018 Apr 26;9:853. doi: 10.3389/fimmu.2018.00853. eCollection 2018. Front Immunol. 2018. PMID: 29755463 Free PMC article. Review.
Cited by
-
IRF3 inhibits inflammatory signaling pathways in macrophages to prevent viral pathogenesis.Sci Adv. 2024 Aug 9;10(32):eadn2858. doi: 10.1126/sciadv.adn2858. Epub 2024 Aug 9. Sci Adv. 2024. PMID: 39121222 Free PMC article.
-
Cytosolic DNA sensors activation of human astrocytes inhibits herpes simplex virus through IRF1 induction.Front Cell Infect Microbiol. 2024 May 14;14:1383811. doi: 10.3389/fcimb.2024.1383811. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38808062 Free PMC article.
-
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.J Virol. 2024 Mar 19;98(3):e0181523. doi: 10.1128/jvi.01815-23. Epub 2024 Feb 29. J Virol. 2024. PMID: 38421179 Free PMC article.
-
Recent Advances in Adenosine-to-Inosine RNA Editing in Cancer.Cancer Treat Res. 2023;190:143-179. doi: 10.1007/978-3-031-45654-1_5. Cancer Treat Res. 2023. PMID: 38113001 Review.
-
Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response.PLoS Pathog. 2023 Oct 23;19(10):e1011742. doi: 10.1371/journal.ppat.1011742. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37871014 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
