Review
doi: 10.1038/nrc2109.
Hyperactive Ras in developmental disorders and cancer
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- PMID: 17384584
- DOI: 10.1038/nrc2109
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Review
Hyperactive Ras in developmental disorders and cancer
Nat Rev Cancer.
2007 Apr.
Erratum in
- Nat Rev Cancer. 2007 Jul;7(7):563
Abstract
Ras genes are the most common targets for somatic gain-of-function mutations in human cancer. Recently, germline mutations that affect components of the Ras-Raf-mitogen-activated and extracellular-signal regulated kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) pathway were shown to cause several developmental disorders, including Noonan, Costello and cardio-facio-cutaneous syndromes. Many of these mutant alleles encode proteins with aberrant biochemical and functional properties. Here we will discuss the implications of germline mutations in the Ras-Raf-MEK-ERK pathway for understanding normal developmental processes and cancer pathogenesis.
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