Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation
- PMID: 17355067
- DOI: 10.1109/TBME.2006.886828
Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation
Abstract
Electrical creation of aqueous pathways across the skin's outer layer [stratum corneum (SC)] provides an approach to transdermal delivery of medium-size water-soluble compounds. However, nerve stimulation should be avoided. Here, we show that a microstructured electrode array can significantly confine the electric field to the nerve-free SC. The prototype electrode-reservoir device (ERD) contains field-confining electrodes and a fluorescent drug surrogate [sulphorhodamine (SR)]. In vivo human experiments at the forearm with approximately rectangular voltage pulses up to 500 V and 1-ms duration cause electroporation as measured by skin resistance change but only rarely caused sensation. Human skin in vitro experiments with such pulses up to 300 V transported SR across the SC. Our results are supported by a model's prediction of the field in the ERD and nearby tissue.
Similar articles
-
Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery.J Control Release. 2006 Feb 21;110(3):557-65. doi: 10.1016/j.jconrel.2005.11.003. Epub 2005 Dec 13. J Control Release. 2006. PMID: 16356576
-
Photomechanical delivery of 100-nm microspheres through the stratum corneum: implications for transdermal drug delivery.Lasers Surg Med. 2002;31(3):207-10. doi: 10.1002/lsm.10099. Lasers Surg Med. 2002. PMID: 12224095
-
Pilot study of topical delivery of methotrexate by electroporation.Br J Dermatol. 2005 Mar;152(3):524-30. doi: 10.1111/j.1365-2133.2005.06455.x. Br J Dermatol. 2005. PMID: 15787822
-
Electrodes for in vivo localised subcutaneous electropulsation and associated drug and nucleic acid delivery.Expert Opin Drug Deliv. 2009 Dec;6(12):1323-31. doi: 10.1517/17425240903294043. Expert Opin Drug Deliv. 2009. PMID: 19860535 Review.
-
Transdermal drug delivery by localized intervention.IEEE Eng Med Biol Mag. 2009 Jan-Feb;28(1):55-63. doi: 10.1109/MEMB.2008.931016. IEEE Eng Med Biol Mag. 2009. PMID: 19150771 Review. No abstract available.
Cited by
-
Numerical study of the electroporation pulse shape effect on molecular uptake of biological cells.Radiol Oncol. 2010 Mar;44(1):34-41. doi: 10.2478/v10019-010-0002-3. Epub 2010 Mar 18. Radiol Oncol. 2010. PMID: 22933889 Free PMC article.
-
An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2110817118. doi: 10.1073/pnas.2110817118. Proc Natl Acad Sci U S A. 2021. PMID: 34670842 Free PMC article.
-
Transdermal drug delivery.Nat Biotechnol. 2008 Nov;26(11):1261-8. doi: 10.1038/nbt.1504. Nat Biotechnol. 2008. PMID: 18997767 Free PMC article. Review.
-
Evolution of Transdermal Drug Delivery Devices and Novel Microneedle Technologies: A Historical Perspective and Review.JID Innov. 2023 Aug 25;3(6):100225. doi: 10.1016/j.xjidi.2023.100225. eCollection 2023 Nov. JID Innov. 2023. PMID: 37744689 Free PMC article. Review.
-
Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Adv Healthc Mater. 2024 Mar;13(7):e2302375. doi: 10.1002/adhm.202302375. Epub 2023 Dec 7. Adv Healthc Mater. 2024. PMID: 38009520 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
