A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid
- PMID: 17347412
- DOI: 10.1126/science.1135882
A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid
Abstract
The plant hormone abscisic acid (ABA) regulates many physiological and developmental processes in plants. The mechanism of ABA perception at the cell surface is not understood. Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein alpha subunit GPA1 to mediate all known ABA responses in Arabidopsis. Overexpressing this receptor results in an ABA-hypersensitive phenotype. This receptor binds ABA with high affinity at physiological concentration with expected kinetics and stereospecificity. The binding of ABA to the receptor leads to the dissociation of the receptor-GPA1 complex in yeast. Our results demonstrate that this G protein-coupled receptor is a plasma membrane ABA receptor.
Comment in
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Botany. A plant receptor with a big family.Science. 2007 Mar 23;315(5819):1676-7. doi: 10.1126/science.1140761. Epub 2007 Mar 8. Science. 2007. PMID: 17347413 No abstract available.
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Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".Science. 2007 Nov 9;318(5852):914; author reply 914. doi: 10.1126/science.1143230. Science. 2007. PMID: 17991845
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