Renal response to repeated exposure to endotoxin: implications for acute kidney injury
- PMID: 17344894
- DOI: 10.1038/sj.ki.5002150
Renal response to repeated exposure to endotoxin: implications for acute kidney injury
Abstract
Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.
Comment on
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'Endotoxin tolerance': TNF-alpha hyper-reactivity and tubular cytoresistance in a renal cholesterol loading state.Kidney Int. 2007 Mar;71(6):496-503. doi: 10.1038/sj.ki.5002092. Epub 2007 Jan 17. Kidney Int. 2007. PMID: 17228359
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