Review
doi: 10.1016/j.cell.2007.01.028.
Beyond the sequence: cellular organization of genome function
Affiliations
- PMID: 17320514
- DOI: 10.1016/j.cell.2007.01.028
Item in Clipboard
Review
Beyond the sequence: cellular organization of genome function
Cell.
.
Free article
Abstract
Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability.
Similar articles
-
Genetic and epigenetic control of the spatial organization of the genome.Mol Biol Cell. 2017 Feb 1;28(3):364-369. doi: 10.1091/mbc.E16-03-0149. Mol Biol Cell. 2017. PMID: 28137949 Free PMC article.
-
[Compartmentalization of the cell nucleus and spatial organization of the genome].Mol Biol (Mosk). 2015 Jan-Feb;49(1):26-45. Mol Biol (Mosk). 2015. PMID: 25916108 Review. Russian.
-
The genome in space and time: does form always follow function? How does the spatial and temporal organization of a eukaryotic genome reflect and influence its functions?Bioessays. 2012 Sep;34(9):800-10. doi: 10.1002/bies.201200034. Epub 2012 Jul 6. Bioessays. 2012. PMID: 22777837 Free PMC article.
-
Dynamics and interplay of nuclear architecture, genome organization, and gene expression.Genes Dev. 2007 Dec 1;21(23):3027-43. doi: 10.1101/gad.1604607. Genes Dev. 2007. PMID: 18056419 Review.
-
Nuclear envelope and chromatin, lock and key of genome integrity.Int Rev Cell Mol Biol. 2015;317:267-330. doi: 10.1016/bs.ircmb.2015.03.001. Epub 2015 Mar 30. Int Rev Cell Mol Biol. 2015. PMID: 26008788 Review.
Cited by
-
Application of Aptamers Improves CRISPR-Based Live Imaging of Plant Telomeres.Front Plant Sci. 2020 Aug 20;11:1254. doi: 10.3389/fpls.2020.01254. eCollection 2020. Front Plant Sci. 2020. PMID: 32973827 Free PMC article.
-
The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.Genes Dev. 2016 May 1;30(9):1101-15. doi: 10.1101/gad.275685.115. Epub 2016 Apr 28. Genes Dev. 2016. PMID: 27125671 Free PMC article.
-
Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.PLoS One. 2012;7(9):e43718. doi: 10.1371/journal.pone.0043718. Epub 2012 Sep 5. PLoS One. 2012. PMID: 22957031 Free PMC article.
-
Chromosome conformation of human fibroblasts grown in 3-dimensional spheroids.Nucleus. 2015;6(1):55-65. doi: 10.1080/19491034.2014.1003745. Nucleus. 2015. PMID: 25738643 Free PMC article.
-
Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation.Chromosoma. 2012 Dec;121(6):539-54. doi: 10.1007/s00412-012-0388-3. Epub 2012 Oct 27. Chromosoma. 2012. PMID: 23104094 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
