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. 2007 Mar 6;581(5):1041-6.
doi: 10.1016/j.febslet.2007.02.007. Epub 2007 Feb 14.

Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana

Valérie Nicaise  1 , Jean-Luc Gallois, Faccila Chafiai, Leah M Allen, Valérie Schurdi-Levraud, Karen S Browning, Thierry Candresse, Carole Caranta, Olivier Le Gall, Sylvie German-Retana
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Free article

Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana

Valérie Nicaise et al. FEBS Lett. .
Free article

Abstract

The translation initiation factors eIF4E and eIF(iso)4E play a key role during virus infection in plants. During mRNA translation, eIF4E provides the cap-binding function and is associated with the protein eIF4G to form the eIF4F complex. Susceptibility analyses of Arabidopsis mutants knocked-out for At-eIF4G genes showed that eIF4G factors are indispensable for potyvirus infection. The colonization pattern by a viral recombinant carrying GFP indicated that eIF4G is involved at a very early infection step. Like eIF4E, eIF4G isoforms are selectively recruited for infection. Moreover, the eIF4G selective involvement parallels eIF4E recruitment. This is the first report of a coordinated and selective recruitment of eIF4E and eIF4G factors, suggesting the whole eIF4F recruitment.

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