doi: 10.1016/j.bbrc.2007.02.019.
Epub 2007 Feb 12.
Protection from lethal influenza virus challenge by oral type 1 interferon
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- PMID: 17316562
- DOI: 10.1016/j.bbrc.2007.02.019
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Protection from lethal influenza virus challenge by oral type 1 interferon
Biochem Biophys Res Commun.
.
Abstract
The persistence of highly pathogenic avian influenza within wild bird populations has forged interest in control measures to limit a possible human pandemic. We therefore investigated the efficacy of low dose oral administration of IFN-alpha as a potential therapy against influenza infection in a murine model. We have identified an optimal low oral dose of IFN-alpha that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 (H1N1). These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control.
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