Debugging how bacteria manipulate the immune response
- PMID: 17307704
- DOI: 10.1016/j.immuni.2007.02.004
Debugging how bacteria manipulate the immune response
Abstract
Beyond the innate response that is elicited when tissues are infected, bacterial pathogens have evolved strategies to subvert the immune response and "recalibrate" it both qualitatively and quantitatively, thereby achieving a balance consistent with the survival of both the microbe and its infected host, a compromise that is likely the result of a long process of coevolution between pathogens and their hosts. By collaboratively studying the mechanisms employed, microbiologists and immunologists are fostering development of a renewed approach of infectious diseases that is expected to provide useful new concepts and applications for their control. In addition, the molecular strategies developed by bacteria to dampen immune mechanisms result from such strong and prolonged selective pressure for survival that they may point to original mechanisms and targets to conceive novel immunomodulatory, anti-inflammatory, and anti-infectious molecules.
Similar articles
-
Bacterial strategies for overcoming host innate and adaptive immune responses.Nat Immunol. 2002 Nov;3(11):1033-40. doi: 10.1038/ni1102-1033. Nat Immunol. 2002. PMID: 12407412 Review.
-
Chronic bacterial infections: living with unwanted guests.Nat Immunol. 2002 Nov;3(11):1026-32. doi: 10.1038/ni1102-1026. Nat Immunol. 2002. PMID: 12407411 Review.
-
Anti-immunology: evasion of the host immune system by bacterial and viral pathogens.Cell. 2006 Feb 24;124(4):767-82. doi: 10.1016/j.cell.2006.01.034. Cell. 2006. PMID: 16497587 Review.
-
[Vaccine development: strategies for coping with the antigenic diversity of bacteria].Rev Sci Tech. 2007 Apr;26(1):91-103. Rev Sci Tech. 2007. PMID: 17633295 Review. French.
-
Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.PLoS Comput Biol. 2005 Nov;1(6):e63. doi: 10.1371/journal.pcbi.0010063. Epub 2005 Nov 18. PLoS Comput Biol. 2005. PMID: 16299590 Free PMC article.
Cited by
-
Impaired dendritic cell maturation and IL-10 production following H. pylori stimulation in gastric cancer patients.Appl Microbiol Biotechnol. 2012 Oct;96(1):211-20. doi: 10.1007/s00253-012-4034-z. Epub 2012 Apr 13. Appl Microbiol Biotechnol. 2012. PMID: 22526791 Free PMC article.
-
Polydnavirus Ank proteins bind NF-κB homodimers and inhibit processing of Relish.PLoS Pathog. 2012;8(5):e1002722. doi: 10.1371/journal.ppat.1002722. Epub 2012 May 24. PLoS Pathog. 2012. PMID: 22654665 Free PMC article.
-
Microbial manipulation of receptor crosstalk in innate immunity.Nat Rev Immunol. 2011 Mar;11(3):187-200. doi: 10.1038/nri2918. Nat Rev Immunol. 2011. PMID: 21350579 Free PMC article. Review.
-
Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2371-6. doi: 10.1073/pnas.0809919106. Epub 2009 Feb 3. Proc Natl Acad Sci U S A. 2009. PMID: 19190178 Free PMC article. Clinical Trial.
-
Immune defence, parasite evasion strategies and their relevance for 'macroscopic phenomena' such as virulence.Philos Trans R Soc Lond B Biol Sci. 2009 Jan 12;364(1513):85-98. doi: 10.1098/rstb.2008.0157. Philos Trans R Soc Lond B Biol Sci. 2009. PMID: 18930879 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
