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Review
. 2007:69:483-510.
doi: 10.1146/annurev.physiol.69.022405.154749.

Beta-arrestins and cell signaling

Scott M DeWire  1 , Seungkirl Ahn, Robert J Lefkowitz, Sudha K Shenoy
Affiliations
Review

Beta-arrestins and cell signaling

Scott M DeWire et al. Annu Rev Physiol. 2007.

Abstract

Upon their discovery, beta-arrestins 1 and 2 were named for their capacity to sterically hinder the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting in receptor desensitization. Surprisingly, recent evidence shows that beta-arrestins can also function to activate signaling cascades independently of G protein activation. By serving as multiprotein scaffolds, the beta-arrestins bring elements of specific signaling pathways into close proximity. beta-Arrestin regulation has been demonstrated for an ever-increasing number of signaling molecules, including the mitogen-activated protein kinases ERK, JNK, and p38 as well as Akt, PI3 kinase, and RhoA. In addition, investigators are discovering new roles for beta-arrestins in nuclear functions. Here, we review the signaling capacities of these versatile adapter molecules and discuss the possible implications for cellular processes such as chemotaxis and apoptosis.

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