Zoned out: functional mapping of stromal signaling microenvironments in the thymus
- PMID: 17291187
- DOI: 10.1146/annurev.immunol.23.021704.115715
Zoned out: functional mapping of stromal signaling microenvironments in the thymus
Abstract
All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this respect, T lymphocytes differ. Under normal circumstances, most T lymphocytes are produced in the thymus from marrow-derived progenitors that circulate in the blood. Cells that home to the thymus from the marrow possess the potential to generate multiple T and non-T lineages. However, there is little evidence to suggest that, once inside the thymus, they give rise to anything other than T cells. Thus, signals unique to the thymic microenvironment compel multipotent progenitors to commit to the T lineage, at the expense of other potential lineages. Summarizing what is known about the signals the thymus delivers to uncommitted progenitors, or to immature T-committed progenitors, to produce functional T cells is the focus of this review.
Similar articles
-
Selective thymus settling regulated by cytokine and chemokine receptors.J Immunol. 2007 Feb 15;178(4):2008-17. doi: 10.4049/jimmunol.178.4.2008. J Immunol. 2007. PMID: 17277104
-
Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment.J Immunol. 2007 Jan 15;178(2):858-68. doi: 10.4049/jimmunol.178.2.858. J Immunol. 2007. PMID: 17202347
-
Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation.Immunity. 2009 Dec 18;31(6):999-1009. doi: 10.1016/j.immuni.2009.09.024. Immunity. 2009. PMID: 20064453 Free PMC article.
-
Journey through the thymus: stromal guides for T-cell development and selection.Nat Rev Immunol. 2006 Feb;6(2):127-35. doi: 10.1038/nri1781. Nat Rev Immunol. 2006. PMID: 16491137 Review.
-
The functional relationship between hematopoietic stem cells and developing T lymphocytes.Ann N Y Acad Sci. 2016 Apr;1370(1):36-44. doi: 10.1111/nyas.12995. Epub 2016 Jan 15. Ann N Y Acad Sci. 2016. PMID: 26773328 Review.
Cited by
-
AIRE deficiency, from preclinical models to human APECED disease.Dis Model Mech. 2021 Feb 5;14(2):dmm046359. doi: 10.1242/dmm.046359. Dis Model Mech. 2021. PMID: 33729987 Free PMC article. Review.
-
Thymus, undernutrition, and infection: Approaching cellular and molecular interactions.Front Nutr. 2022 Sep 26;9:948488. doi: 10.3389/fnut.2022.948488. eCollection 2022. Front Nutr. 2022. PMID: 36225882 Free PMC article. Review.
-
Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.Eur J Immunol. 2017 Jan;47(1):74-83. doi: 10.1002/eji.201646522. Epub 2016 Nov 7. Eur J Immunol. 2017. PMID: 27759161 Free PMC article.
-
Transcriptome sequencing of neonatal thymic epithelial cells.Sci Rep. 2013;3:1860. doi: 10.1038/srep01860. Sci Rep. 2013. PMID: 23681267 Free PMC article.
-
Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence.J R Soc Interface. 2013 Jan 6;10(78):20120774. doi: 10.1098/rsif.2012.0774. J R Soc Interface. 2013. PMID: 23152106 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
