Abnormal wound healing: keloids
- PMID: 17276198
- DOI: 10.1016/j.clindermatol.2006.09.009
Abnormal wound healing: keloids
Abstract
Wound healing is a complex and carefully regulated physiologic response to a traumatic injury. Deregulation of this coordinated process can lead to exuberant scar formation as seen in keloids and hypertrophic scars. Despite their common occurrence, keloids remain one of the most challenging dermatologic conditions to successfully treat and may have significant psychosocial impact for the patient. In this review, we discuss the clinical features, genetics, epidemiology, and treatment of keloids.
Similar articles
-
Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management.Curr Opin Pediatr. 2006 Aug;18(4):396-402. doi: 10.1097/01.mop.0000236389.41462.ef. Curr Opin Pediatr. 2006. PMID: 16914994 Review.
-
Hypertrophic scars and keloids--a review of their pathophysiology, risk factors, and therapeutic management.Dermatol Surg. 2009 Feb;35(2):171-81. doi: 10.1111/j.1524-4725.2008.34406.x. Dermatol Surg. 2009. PMID: 19215252 Review.
-
Scars and keloids.Dermatol Clin. 1993 Oct;11(4):697-708. Dermatol Clin. 1993. PMID: 8222353 Review.
-
Keloids and hypertrophic scars: are they two different sides of the same coin?Dermatol Surg. 2008 Mar;34(3):336-46. doi: 10.1111/j.1524-4725.2007.34067.x. Epub 2007 Dec 19. Dermatol Surg. 2008. PMID: 18177398 Review.
-
Hypertrophic scars and keloids.Clin Podiatr Med Surg. 2001 Jan;18(1):147-59. Clin Podiatr Med Surg. 2001. PMID: 11344975 Review.
Cited by
-
SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis.Inflamm Regen. 2024 Oct 31;44(1):44. doi: 10.1186/s41232-024-00357-y. Inflamm Regen. 2024. PMID: 39482755 Free PMC article.
-
Effects on quality of life and psychosocial wellbeing in Chinese patients with keloids.Am J Transl Res. 2021 Mar 15;13(3):1636-1642. eCollection 2021. Am J Transl Res. 2021. PMID: 33841685 Free PMC article.
-
Wound Healing: A Cellular Perspective.Physiol Rev. 2019 Jan 1;99(1):665-706. doi: 10.1152/physrev.00067.2017. Physiol Rev. 2019. PMID: 30475656 Free PMC article. Review.
-
Efficacy of Topical Losartan in Management of Mammoplasty and Abdominoplasty Scars: A Randomized, Double-Blind Clinical Trial.Aesthetic Plast Surg. 2022 Oct;46(5):2580-2587. doi: 10.1007/s00266-022-02935-2. Epub 2022 May 25. Aesthetic Plast Surg. 2022. PMID: 35614156 Clinical Trial.
-
Downregulated cytotoxic CD8+ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids.Cell Mol Immunol. 2022 Apr;19(4):527-539. doi: 10.1038/s41423-021-00834-1. Epub 2022 Jan 17. Cell Mol Immunol. 2022. PMID: 35039632 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources