doi: 10.1016/j.bbrc.2007.01.092.
Epub 2007 Jan 25.
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle
Affiliations
- PMID: 17275789
- DOI: 10.1016/j.bbrc.2007.01.092
Item in Clipboard
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle
Biochem Biophys Res Commun.
.
Abstract
PGC-1alpha induces mitochondrial biogenesis in muscle and its activity has been related to insulin sensitization. Here, we report that fibrates induce PGC-1alpha gene expression in muscle both in vivo and in vitro. However, only activation via PPARdelta but not PPARalpha underlies this effect. PPARdelta induces PGC-1alpha gene transcription through a PPAR-response element in the PGC-1alpha promoter. Moreover, PGC-1alpha coactivates the PPARdelta-responsiveness of its own gene. A further positive autoregulatory loop of control relies on the induction of PPARdelta expression by PGC-1alpha. These data point to a distinct value of PPARdelta rather than PPARalpha agonists in the improvement of oxidative metabolism in muscle.
Similar articles
-
PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.J Biol Chem. 2009 Jul 10;284(28):18624-33. doi: 10.1074/jbc.M109.008797. Epub 2009 May 12. J Biol Chem. 2009. PMID: 19435887 Free PMC article.
-
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.Mol Cell Biol. 2004 Oct;24(20):9079-91. doi: 10.1128/MCB.24.20.9079-9091.2004. Mol Cell Biol. 2004. PMID: 15456881 Free PMC article.
-
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.Biochim Biophys Acta. 2009 Nov;1791(11):1076-83. doi: 10.1016/j.bbalip.2009.06.005. Epub 2009 Jul 3. Biochim Biophys Acta. 2009. PMID: 19577662
-
Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome.Biochimie. 2004 Nov;86(11):833-7. doi: 10.1016/j.biochi.2004.09.024. Biochimie. 2004. PMID: 15589693 Review.
-
Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta.Curr Diabetes Rev. 2005 Aug;1(3):299-307. doi: 10.2174/157339905774574365. Curr Diabetes Rev. 2005. PMID: 18220606 Review.
Cited by
-
Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure.J Mol Med (Berl). 2019 Apr;97(4):451-462. doi: 10.1007/s00109-019-01756-2. Epub 2019 Feb 21. J Mol Med (Berl). 2019. PMID: 30788535 Review.
-
Immune responses in Parkinson's disease: interplay between central and peripheral immune systems.Biomed Res Int. 2014;2014:275178. doi: 10.1155/2014/275178. Epub 2014 Apr 13. Biomed Res Int. 2014. PMID: 24822191 Free PMC article. Review.
-
Therapeutic Strategies Targeting Mitochondrial Dysfunction in Sepsis-induced Cardiomyopathy.Cardiovasc Drugs Ther. 2024 Feb;38(1):163-180. doi: 10.1007/s10557-022-07354-8. Epub 2022 Jun 15. Cardiovasc Drugs Ther. 2024. PMID: 35704247 Review.
-
Mitochondrial dysfunction in diabetic kidney disease.Nat Rev Nephrol. 2018 May;14(5):291-312. doi: 10.1038/nrneph.2018.9. Epub 2018 Feb 19. Nat Rev Nephrol. 2018. PMID: 29456246 Review.
-
Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder.Int J Mol Sci. 2019 Apr 16;20(8):1878. doi: 10.3390/ijms20081878. Int J Mol Sci. 2019. PMID: 30995737 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
