doi: 10.1016/j.bmcl.2006.12.035.
Epub 2006 Dec 15.
Discovery of thienopyridines as Src-family selective Lck inhibitors
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- PMID: 17234410
- DOI: 10.1016/j.bmcl.2006.12.035
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Discovery of thienopyridines as Src-family selective Lck inhibitors
Bioorg Med Chem Lett.
.
Abstract
We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.
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