Comparative Study
doi: 10.1212/01.wnl.0000254483.19854.ef.
Epub 2007 Jan 10.
Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease
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- PMID: 17215492
- DOI: 10.1212/01.wnl.0000254483.19854.ef
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Comparative Study
Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease
Neurology.
.
Abstract
We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.
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