doi: 10.1016/j.antiviral.2006.11.015.
Epub 2006 Dec 26.
Herpes glycoprotein gL is distantly related to chemokine receptor ligands
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- PMID: 17215049
- DOI: 10.1016/j.antiviral.2006.11.015
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Herpes glycoprotein gL is distantly related to chemokine receptor ligands
Antiviral Res.
2007 Jul.
Abstract
Glycoprotein L (gL) is one of the critical proteins involved in transmission of Herpesviridae. We applied the methodology of protein structure prediction to shed a light on the so far unknown molecular mechanism of its action. Here we show that gL forms a chemokine-like protein. Alphaherpesvirinae gL as well as CMV functional homolog (UL130) create a novel CX chemokine-like protein, while Gammaherpesvirinae gL (HHV8 and EBV) adopt a regular CC beta-chemokine fold. We conclude that gL may interact with specific cellular chemokine receptors during the invasion of Herpesviridae. The proposed mechanism has a potential impact on future development of novel therapeutic and prophylactic strategies.
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