Protein kinases and their therapeutic exploitation
- PMID: 17212579
- DOI: 10.1042/BST0350007
Protein kinases and their therapeutic exploitation
Abstract
This review focuses on the recognition properties of protein kinases at the molecular level. Phosphorylation of the substrate protein by a protein kinase can result in enzyme activation or inhibition, conformational changes that change recognition properties, or the creation of a surface with distinct binding properties. Protein kinases have become important targets for the development of inhibitors with potential therapeutic application. Various examples are considered in this review, and I discuss our own work on glycogen phosphorylase and phosphorylase kinase, and the structures of proteins involved with the cell cycle, including cyclins and cyclin-dependent kinases.
Similar articles
-
Protein kinase inhibitors as a therapeutic modality.Acc Chem Res. 2003 Jun;36(6):462-9. doi: 10.1021/ar0201207. Acc Chem Res. 2003. PMID: 12809533 Review.
-
The development and therapeutic potential of protein kinase inhibitors.Curr Opin Chem Biol. 1999 Aug;3(4):459-65. doi: 10.1016/S1367-5931(99)80067-2. Curr Opin Chem Biol. 1999. PMID: 10419844 Review.
-
Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p.Biochem Biophys Res Commun. 2005 Apr 1;329(1):161-7. doi: 10.1016/j.bbrc.2005.01.106. Biochem Biophys Res Commun. 2005. PMID: 15721288
-
[Glycogen phosphorylase activation by glycogen phosphorylase kinases: dependence on ATP concentration and species specificity of enzymes].Zh Evol Biokhim Fiziol. 2002 Mar-Apr;38(2):187-9. Zh Evol Biokhim Fiziol. 2002. PMID: 12070923 Russian. No abstract available.
-
Advances in glycogen phosphorylase inhibitor design.Curr Opin Investig Drugs. 2008 Apr;9(4):379-95. Curr Opin Investig Drugs. 2008. PMID: 18393105 Review.
Cited by
-
Selectivity of docking sites in MAPK kinases.J Biol Chem. 2009 May 8;284(19):13165-73. doi: 10.1074/jbc.M900080200. Epub 2009 Feb 5. J Biol Chem. 2009. PMID: 19196711 Free PMC article.
-
Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog.Methods Mol Biol. 2017;1647:171-183. doi: 10.1007/978-1-4939-7201-2_11. Methods Mol Biol. 2017. PMID: 28809002 Free PMC article.
-
On the relevance of defining protein structures in cancer research.Clin Transl Oncol. 2008 Apr;10(4):204-12. doi: 10.1007/s12094-008-0183-z. Clin Transl Oncol. 2008. PMID: 18411193 Review.
-
Direct selection of monoclonal phosphospecific antibodies without prior phosphoamino acid mapping.J Biol Chem. 2009 Jul 31;284(31):20791-5. doi: 10.1074/jbc.M109.008730. Epub 2009 May 27. J Biol Chem. 2009. PMID: 19473967 Free PMC article.
-
Multitargeting by curcumin as revealed by molecular interaction studies.Nat Prod Rep. 2011 Nov;28(12):1937-55. doi: 10.1039/c1np00051a. Epub 2011 Oct 6. Nat Prod Rep. 2011. PMID: 21979811 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources