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Review
. 2007 Feb;35(Pt 1):7-11.
doi: 10.1042/BST0350007.

Protein kinases and their therapeutic exploitation

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Review

Protein kinases and their therapeutic exploitation

L Johnson. Biochem Soc Trans. 2007 Feb.

Abstract

This review focuses on the recognition properties of protein kinases at the molecular level. Phosphorylation of the substrate protein by a protein kinase can result in enzyme activation or inhibition, conformational changes that change recognition properties, or the creation of a surface with distinct binding properties. Protein kinases have become important targets for the development of inhibitors with potential therapeutic application. Various examples are considered in this review, and I discuss our own work on glycogen phosphorylase and phosphorylase kinase, and the structures of proteins involved with the cell cycle, including cyclins and cyclin-dependent kinases.

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