doi: 10.1002/jlb.50.5.471.
Murine eosinophil granulocytes bind the murine macrophage-monocyte specific monoclonal antibody F4/80
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- PMID: 1721083
- DOI: 10.1002/jlb.50.5.471
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Murine eosinophil granulocytes bind the murine macrophage-monocyte specific monoclonal antibody F4/80
J Leukoc Biol.
1991 Nov.
Abstract
Studies designed to identify a panel of monoclonal antibodies useful for the separation of murine eosinophil myeloid progenitors revealed that F4/80, an antigen heretofore thought to be expressed only by murine monocyte/macrophage lineage cells, was expressed by eosinophil granulocytes. Eosinophils from several strains of mice stained positively with specific antibody for the epitope. A novel pathway for myeloid differentiation is proposed in which neutrophil progenitors exit a common lineage prior to a common progenitor of monocytes and eosinophils. Moreover, the results demonstrate that binding of anti-F4/80 can no longer be viewed as exclusive for mononuclear phagocytes.
Comment in
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F4/80 monoclonal antibody.J Leukoc Biol. 1992 May;51(5):517-8. J Leukoc Biol. 1992. PMID: 1376355 No abstract available.
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