doi: 10.1038/ncb0107-2.
Defining an epigenetic code
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- PMID: 17199124
- DOI: 10.1038/ncb0107-2
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Defining an epigenetic code
Nat Cell Biol.
2007 Jan.
Abstract
The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.
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