Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
- PMID: 17180163
- DOI: 10.1038/nrn2038
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Abstract
Mounting evidence indicates that microglial activation contributes to neuronal damage in neurodegenerative diseases. Recent studies show that in response to certain environmental toxins and endogenous proteins, microglia can enter an overactivated state and release reactive oxygen species (ROS) that cause neurotoxicity. Pattern recognition receptors expressed on the microglial surface seem to be one of the primary, common pathways by which diverse toxin signals are transduced into ROS production. Overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease.
Similar articles
-
Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells.J Cell Biochem. 2018 Jul;119(7):5609-5619. doi: 10.1002/jcb.26732. Epub 2018 Mar 12. J Cell Biochem. 2018. PMID: 29388693
-
Microglial activation and chronic neurodegeneration.Neurotherapeutics. 2010 Oct;7(4):354-65. doi: 10.1016/j.nurt.2010.05.014. Neurotherapeutics. 2010. PMID: 20880500 Free PMC article.
-
Neuroprotective and toxic changes in microglia in neurodegenerative disease.Parkinsonism Relat Disord. 2009 Jan;15 Suppl 1:S39-41. doi: 10.1016/S1353-8020(09)70011-2. Parkinsonism Relat Disord. 2009. PMID: 19131042 Review.
-
Ion channels on microglia: therapeutic targets for neuroprotection.CNS Neurol Disord Drug Targets. 2011 Feb;10(1):44-56. doi: 10.2174/187152711794488638. CNS Neurol Disord Drug Targets. 2011. PMID: 21143139 Review.
-
Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.J Neuropathol Exp Neurol. 2011 Nov;70(11):1020-35. doi: 10.1097/NEN.0b013e3182358e4e. J Neuropathol Exp Neurol. 2011. PMID: 22002428
Cited by
-
Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response.Mol Brain. 2021 Jun 3;14(1):87. doi: 10.1186/s13041-021-00794-7. Mol Brain. 2021. PMID: 34082793 Free PMC article.
-
Biomolecular Ultrasound Imaging of Phagolysosomal Function.ACS Nano. 2020 Sep 22;14(9):12210-12221. doi: 10.1021/acsnano.0c05912. Epub 2020 Sep 14. ACS Nano. 2020. PMID: 32902951 Free PMC article.
-
α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation.Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1926-35. doi: 10.1073/pnas.1417883112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825709 Free PMC article.
-
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.J Biomed Sci. 2015 Jun 24;22(1):46. doi: 10.1186/s12929-015-0157-8. J Biomed Sci. 2015. PMID: 26100815 Free PMC article.
-
Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration.J Neuroinflammation. 2012 Jun 18;9:130. doi: 10.1186/1742-2094-9-130. J Neuroinflammation. 2012. PMID: 22709825 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
