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Review
. 2006 Dec 8;24(5):643-652.
doi: 10.1016/j.molcel.2006.11.007.

New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors

Robert J Lefkowitz  1 , Keshava Rajagopal  2 , Erin J Whalen  3
Affiliations
Free article
Review

New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors

Robert J Lefkowitz et al. Mol Cell. .
Free article

Abstract

beta-arrestins, originally discovered as molecules that bind to and desensitize the activated and phosphorylated form of the G protein-coupled beta2-adrenergic receptor (beta2-AR), have recently emerged as multifunctional adaptor/scaffold proteins that dynamically assemble a wide range of multiprotein complexes in response to stimulation of most seven-transmembrane receptors (7TMRs). These complexes mediate receptor signaling, trafficking, and degradation. Moreover, beta-arrestins are increasingly found to perform analogous functions for receptors from structurally diverse classes, including atypical 7TMRs such as frizzled and smoothened, the nicotinic cholinergic receptors, receptor tyrosine kinases, and cytokine receptors, thereby regulating a growing list of cellular processes such as chemotaxis, apoptosis, and metastasis.

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