Review
doi: 10.1152/physiol.00032.2006.
Lipid rafts, detergent-resistant membranes, and raft targeting signals
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- PMID: 17119156
- DOI: 10.1152/physiol.00032.2006
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Review
Lipid rafts, detergent-resistant membranes, and raft targeting signals
Physiology (Bethesda).
2006 Dec.
Free article
Abstract
Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.
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