doi: 10.1142/s0219720006002338.
Some comments on instability of false discovery rate estimation
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- PMID: 17099941
- DOI: 10.1142/s0219720006002338
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Some comments on instability of false discovery rate estimation
J Bioinform Comput Biol.
2006 Oct.
Abstract
Some extended false discovery rate (FDR) controlling multiple testing procedures rely heavily on empirical estimates of the FDR constructed from gene expression data. Such estimates are also used as performance indicators when comparing different methods for microarray data analysis. The present communication shows that the variance of the proposed estimators may be intolerably high, the correlation structure of microarray data being the main cause of their instability.
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