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Comparative Study
. 2007 Aug;78(8):819-24.
doi: 10.1136/jnnp.2006.103788. Epub 2006 Nov 10.

Gender differences in Parkinson's disease

Charlotte A Haaxma  1 , Bastiaan R Bloem, George F Borm, Wim J G Oyen, Klaus L Leenders, Silvia Eshuis, Jan Booij, Dean E Dluzen, Martin W I M Horstink
Affiliations
Comparative Study

Gender differences in Parkinson's disease

Charlotte A Haaxma et al. J Neurol Neurosurg Psychiatry. 2007 Aug.

Abstract

Objective: To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD).

Methods: We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration < or = 10 years). We investigated the influence of gender and oestrogen status on: (1) age at onset, (2) presenting symptom, (3) severity and progression of motor symptoms (Unified Parkinson's Disease Rating Scale III (UPDRS-III) scores) and (4) amount and progression of nigrostriatal degeneration ([123I]FP-CIT single photon emission computed tomography measurements).

Results: Age at onset was 2.1 years later in women (53.4 years) than in men (51.3 years). In women, age at onset correlated positively with parity, age at menopause and fertile life span. Women more often presented with tremor (67%) than men (48%). Overall, patients presenting with tremor had a 3.6 year higher age at onset and a 38% slower UPDRS-III deterioration. Mean UPDRS-III scores at disease onset were equal for both genders, as was the rate of deterioration. Women had a 16% higher striatal [123I]FP-CIT binding than men at symptom onset and throughout the course of PD.

Conclusions: Our results suggest that, in women, the development of symptomatic PD may be delayed by higher physiological striatal dopamine levels, possibly due to the activity of oestrogens. This could explain the epidemiological observations of a lower incidence and higher age at onset in women. Women also presented more often with tremor which, in turn, is associated with milder motor deterioration and striatal degeneration. Taken together, these findings suggest a more benign phenotype in women with PD.

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Conflict of interest statement

Competing interests: None.

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References

    1. Van Den Eeden S K, Tanner C M, Berstein A L.et al Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 20031571015–1022. - PubMed
    1. de Lau L M, Giesbergen P C, de Rijk M C.et al Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study. Neurology 2004631240–1244. - PubMed
    1. Wooten G F, Currie L J, Bovbjerg V E.et al Are men at greater risk for Parkinson's disease than women? J Neurol Neurosurg Psychiatry 200475637–639. - PMC - PubMed
    1. Schrag A, Ben‐Shlomo Y, Quinn N P. Cross sectional prevalence survey of idiopathic Parkinson's disease and parkinsonism in London. BMJ 200032121–22. - PMC - PubMed
    1. Claveria L E, Duarte J, Sevillano M D.et al Prevalence of Parkinson's disease in Cantalejo, Spain: a door‐to‐door survey. Mov Disord 200217242–249. - PubMed

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