Review
doi: 10.1007/978-3-540-34344-8_3.
The Rta/Orf50 transactivator proteins of the gamma-herpesviridae
Affiliations
- PMID: 17089794
- DOI: 10.1007/978-3-540-34344-8_3
Item in Clipboard
Review
The Rta/Orf50 transactivator proteins of the gamma-herpesviridae
Curr Top Microbiol Immunol.
2007.
Abstract
The replication and transcription activator protein, Rta, is encoded by Orf50 in Kaposi's sarcoma-associated herpesvirus (KSHV) and other known gammaherpesviruses including Epstein-Barr virus (EBV), rhesus rhadinovirus (RRV), herpesvirus saimiri (HVS), and murine herpesvirus 68 (MHV-68). Each Rta/Orf50 homologue of each gammaherpesvirus plays a pivotal role in the initiation of viral lytic gene expression and lytic reactivation from latency. Here we discuss the Rta/Orf50 of KSHV in comparison to the Rta/Orf50s of other gammaherpesviruses in an effort to identify structural motifs, mechanisms of action, and modulating host factors.
Similar articles
-
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latency.J Virol. 2005 Mar;79(5):3217-22. doi: 10.1128/JVI.79.5.3217-3222.2005. J Virol. 2005. PMID: 15709045 Free PMC article.
-
Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses.J Virol. 2004 May;78(10):5491-9. doi: 10.1128/jvi.78.10.5491-5499.2004. J Virol. 2004. PMID: 15113928 Free PMC article.
-
Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential.J Virol. 2016 Dec 16;91(1):e01434-16. doi: 10.1128/JVI.01434-16. Print 2017 Jan 1. J Virol. 2016. PMID: 27795414 Free PMC article.
-
Lytic cycle switches of oncogenic human gammaherpesviruses.Adv Cancer Res. 2007;97:81-109. doi: 10.1016/S0065-230X(06)97004-3. Adv Cancer Res. 2007. PMID: 17419942 Review.
-
Kaposi's sarcoma-associated herpesvirus immediate early gene activity.Front Biosci. 2004 Sep 1;9:2245-72. doi: 10.2741/1394. Front Biosci. 2004. PMID: 15353285 Review.
Cited by
-
Histone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophages.J Virol. 2010 Nov;84(22):12039-47. doi: 10.1128/JVI.00396-10. Epub 2010 Aug 18. J Virol. 2010. PMID: 20719946 Free PMC article.
-
Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency.J Virol. 2008 May;82(9):4235-49. doi: 10.1128/JVI.02370-07. Epub 2008 Feb 27. J Virol. 2008. PMID: 18305042 Free PMC article.
-
IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors, specificity proteins 1 and 3.J Biol Chem. 2018 Jan 12;293(2):662-676. doi: 10.1074/jbc.M117.802900. Epub 2017 Nov 28. J Biol Chem. 2018. PMID: 29184003 Free PMC article.
-
Diversity and evolution of chromatin proteins encoded by DNA viruses.Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):302-18. doi: 10.1016/j.bbagrm.2009.10.006. Epub 2009 Oct 28. Biochim Biophys Acta. 2010. PMID: 19878744 Free PMC article. Review.
-
Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.PLoS Pathog. 2019 Feb 20;15(2):e1007596. doi: 10.1371/journal.ppat.1007596. eCollection 2019 Feb. PLoS Pathog. 2019. PMID: 30785952 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
