Comparative Study
doi: 10.1038/ng1914.
Epub 2006 Oct 29.
Diversity of microRNAs in human and chimpanzee brain
Affiliations
- PMID: 17072315
- DOI: 10.1038/ng1914
Item in Clipboard
Comparative Study
Diversity of microRNAs in human and chimpanzee brain
Nat Genet.
2006 Dec.
Abstract
We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.
Similar articles
-
Computational identification of novel microRNA homologs in the chimpanzee genome.Comput Biol Chem. 2009 Feb;33(1):62-70. doi: 10.1016/j.compbiolchem.2008.07.024. Epub 2008 Jul 26. Comput Biol Chem. 2009. PMID: 18760970
-
Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals.Mol Biol Evol. 2008 May;25(5):939-48. doi: 10.1093/molbev/msn045. Epub 2008 Feb 14. Mol Biol Evol. 2008. PMID: 18281269
-
Molecular evolution of a primate-specific microRNA family.Mol Biol Evol. 2008 Jul;25(7):1493-502. doi: 10.1093/molbev/msn094. Epub 2008 Apr 15. Mol Biol Evol. 2008. PMID: 18417486
-
Evolution of plant microRNA gene families.Cell Res. 2007 Mar;17(3):212-8. doi: 10.1038/sj.cr.7310113. Cell Res. 2007. PMID: 17130846 Review.
-
The evolution of animal microRNA function.Curr Opin Genet Dev. 2007 Apr;17(2):145-50. doi: 10.1016/j.gde.2007.02.004. Epub 2007 Feb 20. Curr Opin Genet Dev. 2007. PMID: 17317150 Review.
Cited by
-
A Sex Perspective in Neurodegenerative Diseases: microRNAs as Possible Peripheral Biomarkers.Int J Mol Sci. 2021 Apr 23;22(9):4423. doi: 10.3390/ijms22094423. Int J Mol Sci. 2021. PMID: 33922607 Free PMC article. Review.
-
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees.Genome Biol Evol. 2015 Jul 10;7(8):2276-88. doi: 10.1093/gbe/evv132. Genome Biol Evol. 2015. PMID: 26163674 Free PMC article.
-
Evolutionary Transitions of MicroRNA-Target Pairs.Genome Biol Evol. 2016 Jun 4;8(5):1621-33. doi: 10.1093/gbe/evw092. Genome Biol Evol. 2016. PMID: 27189995 Free PMC article.
-
Host gene constraints and genomic context impact the expression and evolution of human microRNAs.Nat Commun. 2016 Apr 25;7:11438. doi: 10.1038/ncomms11438. Nat Commun. 2016. PMID: 27109497 Free PMC article.
-
Concise review: MicroRNA expression in multipotent mesenchymal stromal cells.Stem Cells. 2008 Feb;26(2):356-63. doi: 10.1634/stemcells.2007-0625. Epub 2007 Nov 8. Stem Cells. 2008. PMID: 17991914 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
