Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
- PMID: 17063034
- DOI: 10.1159/000096557
Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
Abstract
Dietary restriction (DR) remains the most powerful and general environmental manipulation of aging processes in laboratory animals with strong beneficial effects on most age-related degenerative changes throughout the body. Underlying the beneficial effects of DR is the attenuation of system-wide inflammatory processes including those occurring within the central nervous system. During normal aging a progressive neuroinflammatory state builds in the brain involving astrocytes and microglia, the primary cellular components of neuroinflammation. DR attenuates the age-related activation of astrocytes and microglia with concomitant beneficial effects on neurodegeneration and cognition. Increasing evidence suggests that common pathways are emerging that link many normal aging inflammatory processes with age-related diseases such as Alzheimer, cancer, diabetes and cardiovascular disease.
Similar articles
-
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity.Mol Aspects Med. 2011 Aug;32(4-6):279-304. doi: 10.1016/j.mam.2011.10.007. Epub 2011 Oct 15. Mol Aspects Med. 2011. PMID: 22020114 Review.
-
Dietary restriction in aging nonhuman primates.Interdiscip Top Gerontol. 2007;35:137-58. doi: 10.1159/000096560. Interdiscip Top Gerontol. 2007. PMID: 17063037 Review.
-
[Caloric restriction in primates: how efficient as an anti-aging approach?].Med Sci (Paris). 2012 Dec;28(12):1081-6. doi: 10.1051/medsci/20122812018. Epub 2012 Dec 21. Med Sci (Paris). 2012. PMID: 23290408 Review. French.
-
Aging microglia: relevance to cognition and neural plasticity.Methods Mol Biol. 2012;934:193-218. doi: 10.1007/978-1-62703-071-7_11. Methods Mol Biol. 2012. PMID: 22933148
-
Flies and their golden apples: the effect of dietary restriction on Drosophila aging and age-dependent gene expression.Ageing Res Rev. 2005 Nov;4(4):451-80. doi: 10.1016/j.arr.2005.06.007. Epub 2005 Nov 2. Ageing Res Rev. 2005. PMID: 16263339 Review.
Cited by
-
Regulation of energy balance by inflammation: common theme in physiology and pathology.Rev Endocr Metab Disord. 2015 Mar;16(1):47-54. doi: 10.1007/s11154-014-9306-8. Rev Endocr Metab Disord. 2015. PMID: 25526866 Free PMC article. Review.
-
mTOR is a key modulator of ageing and age-related disease.Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861. Nature. 2013. PMID: 23325216 Free PMC article. Review.
-
Insulin effect on glucose transport in thymocytes and splenocytes from rats with metabolic syndrome.Diabetol Metab Syndr. 2010 Nov 2;2:64. doi: 10.1186/1758-5996-2-64. Diabetol Metab Syndr. 2010. PMID: 21044347 Free PMC article.
-
Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene.Brain Res. 2008 Nov 19;1241:18-28. doi: 10.1016/j.brainres.2008.09.011. Epub 2008 Sep 16. Brain Res. 2008. PMID: 18822276 Free PMC article.
-
Neurogenesis, inflammation and behavior.Brain Behav Immun. 2013 Jan;27(1):22-32. doi: 10.1016/j.bbi.2012.09.003. Epub 2012 Sep 15. Brain Behav Immun. 2013. PMID: 22985767 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
