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Randomized Controlled Trial
. 2007 Jan;41(1):29-33.
doi: 10.1136/bjsm.2006.030130. Epub 2006 Oct 24.

A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression

K Knubben  1 , F M Reischies, M Adli, P Schlattmann, M Bauer, F Dimeo
Affiliations
Randomized Controlled Trial

A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression

K Knubben et al. Br J Sports Med. 2007 Jan.

Abstract

Objective: To evaluate the short-term effects of exercise in patients with major depression.

Design: Prospective, randomised, controlled study.

Setting: A university hospital.

Patients: A consecutive series of 38 inpatients with a major depression episode undergoing standard clinical antidepressant drug treatment.

Interventions: Patients were randomly assigned to an exercise (walking, n = 20) or placebo (low-intensity stretching and relaxation exercises, n = 18) group. Training was carried out for 10 days.

Main outcome measurements: Severity of depression assessed with the Bech-Rafaelsen Melancholy Scale (BRMS) and the Center for Epidemiologic Studies Depression scale (CES-D).

Results: After 10 days, reduction of depression scores in the exercise group was significantly larger than in the placebo group (BRMS: 36% v 18%; CES-D: 41% v 21%; p for both = 0.01); the proportion of patients with a clinical response (reduction in the BRMS scores by more than six points) was also larger for the exercise group (65% v 22%, p<0.01).

Conclusions: Endurance exercise may help to achieve substantial improvement in the mood of selected patients with major depression in a short time.

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Conflict of interest statement

Competing interests: None.

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References

    1. Scully D, Kremer J, Meade M M.et al Physical exercise and psychological well being: a critical review. Br J Sports Med 199832111–120. - PMC - PubMed
    1. Yeung R R. The acute effects of exercise on mood state. J Psychosom Res 199640123–141. - PubMed
    1. North T C, McCullagh P, Tran Z V. Effect of exercise on depression. Exerc Sport Sci Rev 199018379–415. - PubMed
    1. Craft L L, Landers D M. The effect of exercise on clinical depression and depression resulting from mental illness: a meta‐analysis. J Sport Exerc Psychol 199820339–357.
    1. Lawlor D A, Hopker S W. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta‐regression analysis of randomised controlled trials. BMJ 2001322763–767. - PMC - PubMed

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