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. 2006 Oct 6;314(5796):136-9.
doi: 10.1126/science.1131920.

Modulation of cell adhesion and motility in the immune system by Myo1f

Sangwon V Kim  1 , Wajahat Z Mehal, Xuemei Dong, Volkmar Heinrich, Marc Pypaert, Ira Mellman, Micah Dembo, Mark S Mooseker, Dianqing Wu, Richard A Flavell
Affiliations

Modulation of cell adhesion and motility in the immune system by Myo1f

Sangwon V Kim et al. Science. .

Abstract

Although class I myosins are known to play a wide range of roles, the physiological function of long-tailed class I myosins in vertebrates remains elusive. We demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system. Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta2 integrin-containing granules. Also, the cortical actin that co-localizes with Myo1f was reduced in Myo1f-deficient cells. In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection.

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