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Comparative Study
. 1990 Sep;9(9):873-82.
doi: 10.3109/02713689008999559.

Discrimination between the lens fiber cell 115 kd cytoskeletal protein and alpha-actinin

P G FitzGerald  1 , J Casselman
Affiliations
Comparative Study

Discrimination between the lens fiber cell 115 kd cytoskeletal protein and alpha-actinin

P G FitzGerald et al. Curr Eye Res. 1990 Sep.

Abstract

The lens fiber cell cytoskeleton includes a protein with a relative molecular weight, by SDS PAGE, of 115 kD. This protein has been purported to be, or be related to alpha-actinin, a highly-conserved family of actin-binding cytoskeletal proteins common to many tissues across a wide phylogenetic range. In this report we assess the relationship between the 115 kd lens fiber cell protein and alpha-actinin. Assessment of relative molecular weight, immunologic cross-reactivity, and partial sequence analysis suggest that the 115 kD lens fiber cell cytoskeletal protein and alpha-actinin are either unrelated, or, at best, that the lens protein represents an unusually divergent isoform of the alpha-actin family of proteins. Immunochemical analysis of homogenates of bovine heart and red blood cells indicate that these tissues express a protein which is weakly cross-reactive with the lens 115 kD protein, but that this cross-reactive protein is not alpha-actinin.

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