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. 2006 Oct;39(5):403-14.
doi: 10.1111/j.1365-2184.2006.00396.x.

An enteroendocrine cell-based model for a quiescent intestinal stem cell niche

I R Radford  1 , P N Lobachevsky
Affiliations

An enteroendocrine cell-based model for a quiescent intestinal stem cell niche

I R Radford et al. Cell Prolif. 2006 Oct.

Abstract

We have shown that the kinetics of conversion of intestinal crypt cell populations to a partially or wholly mutant phenotype are consistent with a model in which each crypt contains an infrequently dividing 'deep' stem cell that is the progenitor of several more frequently dividing 'proximate' stem cells. An assumption of our model is that each deep stem cell exists in a growth inhibitory niche. We have used information from the literature to develop a model for a quiescent intestinal stem cell niche. This niche is postulated to be primarily defined by an enteroendocrine cell type that maintains stem cell quiescence by secretion of growth inhibitory peptides such as somatostatin and guanylin/uroguanylin. Consistent with this model, there is evidence that the proteins postulated as defining a growth-inhibitory stem cell niche can act as intestinal tumour suppressors. Confirmation that a growth-inhibitory niche does exist would have important implications for our understanding of intestinal homeostasis and tumorigenesis.

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Figures

Figure 1
Figure 1
Basic features of the proposed intestinal deep stem cell niche.
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