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. 2006 Nov 15;174(10):1094-100.
doi: 10.1164/rccm.200605-722OC. Epub 2006 Sep 14.

Regular smoking and asthma incidence in adolescents

Frank D Gilliland  1 , Talat Islam, Kiros Berhane, W James Gauderman, Rob McConnell, Edward Avol, John M Peters
Affiliations

Regular smoking and asthma incidence in adolescents

Frank D Gilliland et al. Am J Respir Crit Care Med. .

Abstract

Rationale: Although involuntary exposure to maternal smoking during the in utero period and to secondhand smoke are associated with occurrence of childhood asthma, few studies have investigated the role of active cigarette smoking on asthma onset during adolescence.

Objectives: To determine whether regular smoking is associated with the new onset of asthma during adolescence.

Methods: We conducted a prospective cohort study among 2,609 children with no lifetime history of asthma or wheezing who were recruited from fourth- and seventh-grade classrooms and followed annually in schools in 12 southern California communities. Regular smoking was defined as smoking at least seven cigarettes per day on average over the week before and 300 cigarettes in the year before each annual interview. Incident asthma was defined using new cases of physician-diagnosed asthma.

Measurements and main results: Regular smoking was associated with increased risk of new-onset asthma. Children who reported smoking 300 or more cigarettes per year had a relative risk (RR) of 3.9 (95% confidence interval [95% CI], 1.7-8.5) for new-onset asthma compared with nonsmokers. The increased risk from regular smoking was greater in nonallergic than in allergic children. Regular smokers who were exposed to maternal smoking during gestation had the largest risk from active smoking (RR, 8.8; 95% CI, 3.2-24.0).

Conclusions: Regular smoking increased risk for asthma among adolescents, especially for nonallergic adolescents and those exposed to maternal smoking during the in utero period.

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References

    1. US Department of Health and Human Services, Centers For Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office of Smoking and Health. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA; 2004.
    1. Higgins MW, Keller JB, Metzner HL. Smoking, socioeconomic status, and chronic respiratory disease. Am Rev Respir Dis 1977;116:403–410. - PubMed
    1. Chen Y, Dales R, Krewski D, Breithaupt K. Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994–1995. Am J Epidemiol 1999;150:255–262. - PubMed
    1. McWhorter WP, Polis MA, Kaslow RA. Occurrence, predictors, and consequences of adult asthma in NHANESI and follow-up survey. Am Rev Respir Dis 1989;139:721–724. - PubMed
    1. Plaschke PP, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B. Onset and remission of allergic rhinitis and asthma and the relationship with atopic sensitization and smoking. Am J Respir Crit Care Med 2000;162:920–924. - PubMed

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