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Comparative Study
. 2006 Dec 15;108(13):4288-90.
doi: 10.1182/blood-2006-05-024042. Epub 2006 Aug 31.

Long-term outcome of patients given transplants of mobilized blood or bone marrow: A report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation

Norbert Schmitz  1 , Mary Eapen, Mary M Horowitz, Mei-Jie Zhang, John P Klein, J Douglas Rizzo, Fausto R Loberiza, Alois Gratwohl, Richard E Champlin; International Bone Marrow Transplant Registry; European Group for Blood and Marrow Transplantation
Affiliations
Comparative Study

Long-term outcome of patients given transplants of mobilized blood or bone marrow: A report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation

Norbert Schmitz et al. Blood. .

Abstract

We previously compared outcomes after allogeneic peripheral-blood stem cell (PBSC) and bone marrow (BM) transplantation in 706 patients with leukemia. We obtained long-term follow up on 413 of 491 patients who were alive at the time of the initial report: 141 PBSC and 272 BM recipients. Chronic graft-versus-host disease (GVHD) was more frequent after PBSC compared to BM transplantation (RR 1.65, P < .001) yet relapse rates were similar in both groups. Leukemia-free survival rates were higher after PBSC than BM transplantation for patients with advanced chronic myeloid leukemia (33% versus 25%) but lower for those in first chronic phase (41% versus 61%) due to higher rates of late transplant-related mortality. Leukemia-free survival was similar after PBSC and BM transplantation for acute leukemia. These data represent the early experience with PBSC grafts. Long-term outcomes in recipients of more recent transplants are required to better evaluate the role of PBSC grafts relative to BM transplantation.

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Figures

Figure 1.
Figure 1.
TRM and LFS in patients with acute and chronic leukemia after BM and PBSC transplantation. (A) Cumulative incidence of TRM in patients with acute leukemia after BM and PBSC transplantation adjusted for disease status at transplantation (n, number of evaluable patients; %, the 6-year rate of TRM). (B) Cumulative incidence of TRM in patients with chronic leukemia after BM and PBSC transplantation adjusted for disease status at transplantation (n, number of evaluable patients; %, 6-year rate of TRM). (C) Probability of LFS in patients with acute leukemia after BM and PBSC transplantation adjusted for disease status at transplantation (n, number of evaluable patients; %, 6-year rate of LFS). (D) Probability of LFS in patients with chronic leukemia after BM and PBSC transplantation adjusted for disease status at transplantation (n, number of evaluable patients; %, 6-year rate of LFS).
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