Structure and function of nucleosome assembly proteins
- PMID: 16936827
- DOI: 10.1139/o06-088
Structure and function of nucleosome assembly proteins
Abstract
Homologues of nucleosome assembly protein 1 (NAP1) have been identified in all eukaryotes. Although initially identified as histone chaperones and chromatin-assembly factors, additional functions include roles in tissue-specific transcription regulation, apoptosis, histone shuttling, and cell-cycle regulation, and extend beyond those of a simple chaperone and assembly factor. NAP1 family members share a structurally conserved fold, the NAP domain. Here we review current knowledge of the NAP family of proteins within the context of the recently determined crystal structure of the NAP1 family's first representative, NAP1 from yeast.
Similar articles
-
[Chromatin assembly in vitro with a linker histone chaperone NAP-1].Seikagaku. 2006 May;78(5):421-5. Seikagaku. 2006. PMID: 16780115 Review. Japanese. No abstract available.
-
Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.Mol Cell Biol. 2008 Apr;28(7):2113-24. doi: 10.1128/MCB.02136-07. Epub 2008 Jan 28. Mol Cell Biol. 2008. PMID: 18227150 Free PMC article.
-
Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.Mol Cell Biol. 2005 Dec;25(23):10639-51. doi: 10.1128/MCB.25.23.10639-10651.2005. Mol Cell Biol. 2005. PMID: 16287874 Free PMC article.
-
Nap1: taking a closer look at a juggler protein of extraordinary skills.FASEB J. 2007 May;21(7):1294-310. doi: 10.1096/fj.06-7199rev. Epub 2007 Feb 22. FASEB J. 2007. PMID: 17317729 Review.
-
[Physiological functions of the acidic molecular chaperone Nap1].Seikagaku. 2005 Mar;77(3):206-12. Seikagaku. 2005. PMID: 15835307 Review. Japanese. No abstract available.
Cited by
-
Fluorescence strategies for high-throughput quantification of protein interactions.Nucleic Acids Res. 2012 Mar;40(5):e33. doi: 10.1093/nar/gkr1045. Epub 2011 Nov 24. Nucleic Acids Res. 2012. PMID: 22121211 Free PMC article.
-
KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription.Sci Rep. 2016 Sep 7;6:32633. doi: 10.1038/srep32633. Sci Rep. 2016. PMID: 27599637 Free PMC article.
-
Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation.Mol Cancer. 2010 Sep 2;9:230. doi: 10.1186/1476-4598-9-230. Mol Cancer. 2010. PMID: 20813049 Free PMC article.
-
Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities.Mol Cell. 2003 Dec;12(6):1599-606. doi: 10.1016/s1097-2765(03)00499-4. Mol Cell. 2003. PMID: 14690611 Free PMC article.
-
Histone chaperones link histone nuclear import and chromatin assembly.Biochim Biophys Acta. 2012 Mar;1819(3-4):277-89. doi: 10.1016/j.bbagrm.2011.09.007. Epub 2011 Oct 8. Biochim Biophys Acta. 2012. PMID: 22015777 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous