extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins
- PMID: 1690604
- DOI: 10.1016/0092-8674(90)90212-w
extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins
Abstract
The function of the extramacrochaetae (emc) gene is required to establish the normal spatial pattern of adult sensory organs in Drosophila. emc acts to suppress sensory organ development in certain regions of the body surface, apparently by antagonizing the function of the achaete and scute genes of the achaetescute complex (AS.C). We have found that emc encodes a novel member of the helix-loop-helix (HLH) family of proteins. The emc protein shares the dimerization domain of other HLH proteins but lacks their DNA binding motif. We propose a model in which the emc protein negatively regulates sensory organ determination by forming heterodimers with the HLH proteins encoded by the AS-C and/or daughterless, thereby altering or interfering with their activity.
Similar articles
-
The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.Cell. 1990 Apr 6;61(1):39-48. doi: 10.1016/0092-8674(90)90213-x. Cell. 1990. PMID: 1690605
-
Embryonic expression and function of the Drosophila helix-loop-helix gene, extramacrochaetae.Mech Dev. 1994 Jul;47(1):65-72. doi: 10.1016/0925-4773(94)90096-5. Mech Dev. 1994. PMID: 7947322
-
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes.Development. 1991 Sep;113(1):245-55. doi: 10.1242/dev.113.1.245. Development. 1991. PMID: 1764999
-
Emc, a negative HLH regulator with multiple functions in Drosophila development.Oncogene. 2001 Dec 20;20(58):8299-307. doi: 10.1038/sj.onc.1205162. Oncogene. 2001. PMID: 11840322 Review.
-
The genetics of the Drosophila achaete-scute gene complex: a historical appraisal.Int J Dev Biol. 1998;42(3):291-7. Int J Dev Biol. 1998. PMID: 9654011 Review.
Cited by
-
Interaction of basal positive and negative transcription elements controls repression of the proximal rat prolactin promoter in nonpituitary cells.Mol Cell Biol. 1992 Jun;12(6):2708-19. doi: 10.1128/mcb.12.6.2708-2719.1992. Mol Cell Biol. 1992. PMID: 1610473 Free PMC article.
-
Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.Genetics. 1991 Nov;129(3):803-23. doi: 10.1093/genetics/129.3.803. Genetics. 1991. PMID: 1752423 Free PMC article.
-
Helix-loop-helix transcription factors mediate activation and repression of the p75LNGFR gene.Mol Cell Biol. 1995 Nov;15(11):6036-44. doi: 10.1128/MCB.15.11.6036. Mol Cell Biol. 1995. PMID: 7565756 Free PMC article.
-
Initial neurogenesis in Drosophila.Wiley Interdiscip Rev Dev Biol. 2013 Sep-Oct;2(5):701-21. doi: 10.1002/wdev.111. Epub 2013 Feb 11. Wiley Interdiscip Rev Dev Biol. 2013. PMID: 24014455 Free PMC article. Review.
-
The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3.Nucleic Acids Res. 1994 Mar 11;22(5):749-55. doi: 10.1093/nar/22.5.749. Nucleic Acids Res. 1994. PMID: 8139914 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
