Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
- PMID: 16902972
- DOI: 10.1002/pros.20488
Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
Abstract
Background: The ARCaP cell line was established from the ascites fluid of a patient with metastatic prostate cancer. This study characterized the host microenvironmental role in cancer progression, epithelial to mesenchymal transition (EMT), and bone and adrenal metastasis in parental ARCaP and its derived cell subclones.
Methods: Cytogenetic profiles, growth, migration, invasion, cellular interaction, drug sensitivities, and gene expression of ARCaP cell subclones were compared. In vivo gene expression, behavior, and metastasis of ARCaP subclones were analyzed by serial intracardiac injections into SCID mice.
Results: ARCaP(E) cells, with cobblestone morphology, underwent EMT through cellular interaction with host bone and adrenal gland. Lineage-derived ARCaP(M) cells, with spindle-shape fibroblastic morphology, exhibited decreased cell adhesion and increased metastasis to bone and adrenal gland. Cytogenetic analyses of parental and ARCaP subclones confirmed their clonality.
Conclusions: ARCaP uniquely models the molecular basis of prostate cancer bone and adrenal metastases and epithelial to mesenchymal transition.
Similar articles
-
Molecular insights into prostate cancer progression: the missing link of tumor microenvironment.J Urol. 2005 Jan;173(1):10-20. doi: 10.1097/01.ju.0000141582.15218.10. J Urol. 2005. PMID: 15592017 Review.
-
[Epithelial-mesenchymal transition in cancer progression].Postepy Biochem. 2009;55(2):121-8. Postepy Biochem. 2009. PMID: 19824467 Review. Polish.
-
Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells.Cell Res. 2008 Aug;18(8):858-70. doi: 10.1038/cr.2008.84. Cell Res. 2008. PMID: 18645583
-
Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells.Endocr Relat Cancer. 2005 Sep;12(3):631-43. doi: 10.1677/erc.1.00958. Endocr Relat Cancer. 2005. PMID: 16172196
-
Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2.Cancer Res. 2006 Dec 1;66(23):11271-8. doi: 10.1158/0008-5472.CAN-06-2044. Cancer Res. 2006. PMID: 17145872
Cited by
-
Cellular Plasticity in Prostate Cancer Bone Metastasis.Prostate Cancer. 2015;2015:651580. doi: 10.1155/2015/651580. Epub 2015 Jun 3. Prostate Cancer. 2015. PMID: 26146569 Free PMC article. Review.
-
Fatty Acid Signaling Impacts Prostate Cancer Lineage Plasticity in an Autocrine and Paracrine Manner.Cancers (Basel). 2022 Jul 15;14(14):3449. doi: 10.3390/cancers14143449. Cancers (Basel). 2022. PMID: 35884514 Free PMC article.
-
The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer.Cancer Growth Metastasis. 2013 Nov 27;6:61-80. doi: 10.4137/CGM.S12769. eCollection 2013. Cancer Growth Metastasis. 2013. PMID: 24665208 Free PMC article. Review.
-
Circulating melanoma cells in the diagnosis and monitoring of melanoma: an appraisal of clinical potential.Mol Diagn Ther. 2014 Apr;18(2):175-83. doi: 10.1007/s40291-013-0071-2. Mol Diagn Ther. 2014. PMID: 24297151 Free PMC article. Review.
-
Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor.Biomaterials. 2015 Oct;67:1-10. doi: 10.1016/j.biomaterials.2015.07.028. Epub 2015 Jul 16. Biomaterials. 2015. PMID: 26197410 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
