Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk
- PMID: 16860760
- DOI: 10.1016/j.immuni.2006.05.011
Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk
Erratum in
- Immunity. 2006 Nov;25(5):849. Fleischecker, Christine [corrected to Fleischacker, Christine]
Abstract
Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless, we find that CD8 single-positive (SP) thymocytes and peripheral CD8(+) T cells in these mice do not resemble conventional CD8(+) T cells. Instead, these cells express memory markers, rapidly produce interferon-gamma, and can be selected on hematopoietically derived cells, similar to MHC class Ib-restricted "innate-type" lymphocytes. Itk deficiency also greatly increases the number of cells selected by MHC class Ib. Expression of a hypersensitive Erk2 mutant partially corrects the CD8(+) T cell phenotypes in Itk(-/-) mice, arguing that altered signaling permits development of this innate-type CD8(+) cell population. Our results suggest that Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes.
Comment in
-
Tec kinases in T cell development: a clue behind the mask?Immunity. 2006 Jul;25(1):9-11. doi: 10.1016/j.immuni.2006.07.006. Immunity. 2006. PMID: 16860750
Similar articles
-
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.Immunity. 2006 Jul;25(1):79-91. doi: 10.1016/j.immuni.2006.05.012. Immunity. 2006. PMID: 16860759
-
Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.Nat Rev Immunol. 2007 Jun;7(6):479-85. doi: 10.1038/nri2091. Nat Rev Immunol. 2007. PMID: 17479128 Review.
-
The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.Immunol Rev. 2009 Mar;228(1):115-31. doi: 10.1111/j.1600-065X.2008.00746.x. Immunol Rev. 2009. PMID: 19290924 Free PMC article. Review.
-
The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.J Immunol. 2008 Mar 1;180(5):3007-18. doi: 10.4049/jimmunol.180.5.3007. J Immunol. 2008. PMID: 18292523
-
Tec family kinases modulate thresholds for thymocyte development and selection.J Exp Med. 2000 Oct 2;192(7):987-1000. doi: 10.1084/jem.192.7.987. J Exp Med. 2000. PMID: 11015440 Free PMC article.
Cited by
-
Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.J Immunol. 2013 Aug 15;191(4):1704-15. doi: 10.4049/jimmunol.1300417. Epub 2013 Jul 12. J Immunol. 2013. PMID: 23851691 Free PMC article.
-
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.Immunity. 2007 Nov;27(5):751-62. doi: 10.1016/j.immuni.2007.08.020. Immunity. 2007. PMID: 18031695 Free PMC article.
-
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance.J Exp Med. 2010 Feb 15;207(2):309-18. doi: 10.1084/jem.20090880. Epub 2010 Feb 1. J Exp Med. 2010. PMID: 20123962 Free PMC article.
-
Biochemical signaling pathways for memory T cell recall.Semin Immunol. 2009 Apr;21(2):84-91. doi: 10.1016/j.smim.2009.02.003. Semin Immunol. 2009. PMID: 19298946 Free PMC article. Review.
-
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.Immunity. 2008 Mar;28(3):359-69. doi: 10.1016/j.immuni.2008.01.010. Immunity. 2008. PMID: 18342008 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
