BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments
- PMID: 16845052
- PMCID: PMC1538844
- DOI: 10.1093/nar/gkl172
BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments
Abstract
We present a new version of Babelomics, a complete suite of web tools for functional analysis of genome-scale experiments, with new and improved tools. New functionally relevant terms have been included such as CisRed motifs or bioentities obtained by text-mining procedures. An improved indexing has considerably speeded up several of the modules. An improved version of the FatiScan method for studying the coordinate behaviour of groups of functionally related genes is presented, along with a similar tool, the Gene Set Enrichment Analysis. Babelomics is now more oriented to test systems biology inspired hypotheses. Babelomics can be found at http://www.babelomics.org.
Similar articles
-
BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W460-4. doi: 10.1093/nar/gki456. Nucleic Acids Res. 2005. PMID: 15980512 Free PMC article.
-
FatiGO +: a functional profiling tool for genomic data. Integration of functional annotation, regulatory motifs and interaction data with microarray experiments.Nucleic Acids Res. 2007 Jul;35(Web Server issue):W91-6. doi: 10.1093/nar/gkm260. Epub 2007 May 3. Nucleic Acids Res. 2007. PMID: 17478504 Free PMC article.
-
From genes to functional classes in the study of biological systems.BMC Bioinformatics. 2007 Apr 3;8:114. doi: 10.1186/1471-2105-8-114. BMC Bioinformatics. 2007. PMID: 17407596 Free PMC article.
-
The application of systems biology to drug discovery.Curr Opin Chem Biol. 2006 Aug;10(4):294-302. doi: 10.1016/j.cbpa.2006.06.025. Epub 2006 Jul 5. Curr Opin Chem Biol. 2006. PMID: 16822703 Review.
-
Functional genomics databases on the web.Cell Microbiol. 2005 Aug;7(8):1053-9. doi: 10.1111/j.1462-5822.2005.00553.x. Cell Microbiol. 2005. PMID: 16008573 Review.
Cited by
-
Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.BMC Genomics. 2012 Sep 15;13:483. doi: 10.1186/1471-2164-13-483. BMC Genomics. 2012. PMID: 22978642 Free PMC article.
-
The forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast.J Biol Chem. 2010 Nov 19;285(47):37092-101. doi: 10.1074/jbc.M110.174763. Epub 2010 Sep 16. J Biol Chem. 2010. PMID: 20847055 Free PMC article.
-
Plastidial glyceraldehyde-3-phosphate dehydrogenase deficiency leads to altered root development and affects the sugar and amino acid balance in Arabidopsis.Plant Physiol. 2009 Oct;151(2):541-58. doi: 10.1104/pp.109.143701. Epub 2009 Aug 12. Plant Physiol. 2009. PMID: 19675149 Free PMC article.
-
Inferring biological functions and associated transcriptional regulators using gene set expression coherence analysis.BMC Bioinformatics. 2007 Nov 17;8:453. doi: 10.1186/1471-2105-8-453. BMC Bioinformatics. 2007. PMID: 18021416 Free PMC article.
-
Genome and proteome annotation: organization, interpretation and integration.J R Soc Interface. 2009 Feb 6;6(31):129-47. doi: 10.1098/rsif.2008.0341. J R Soc Interface. 2009. PMID: 19019817 Free PMC article. Review.
References
-
- Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F.H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., et al. A human protein–protein interaction network: a resource for annotating the proteome. Cell. 2005;122:957–968. - PubMed
-
- Rual J.F., Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz G.F., Gibbons F.D., Dreze M., Ayivi-Guedehoussou N., et al. Towards a proteome-scale map of the human protein–protein interaction network. Nature. 2005;437:1173–1178. - PubMed
-
- Hallikas O., Palin K., Sinjushina N., Rautiainen R., Partanen J., Ukkonen E., Taipale J. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell. 2006;124:47–59. - PubMed
-
- Stuart J.M., Segal E., Koller D., Kim S.K. A gene-coexpression network for global discovery of conserved genetic modules. Science. 2003;302:249–255. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources