Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
- PMID: 16839884
- DOI: 10.1016/j.cell.2006.06.021
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
Abstract
Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial signaling pathways. Presenilin-associated rhomboid-like (PARL) is an inner mitochondrial membrane rhomboid of unknown function, whose yeast ortholog is involved in mitochondrial fusion. Parl-/- mice display normal intrauterine development but from the fourth postnatal week undergo progressive multisystemic atrophy leading to cachectic death. Atrophy is sustained by increased apoptosis, both in and ex vivo. Parl-/- cells display normal mitochondrial morphology and function but are no longer protected against intrinsic apoptotic death stimuli by the dynamin-related mitochondrial protein OPA1. Parl-/- mitochondria display reduced levels of a soluble, intermembrane space (IMS) form of OPA1, and OPA1 specifically targeted to IMS complements Parl-/- cells, substantiating the importance of PARL in OPA1 processing. Parl-/- mitochondria undergo faster apoptotic cristae remodeling and cytochrome c release. These findings implicate regulated intramembrane proteolysis in controlling apoptosis.
Comment in
-
OPA1 and PARL keep a lid on apoptosis.Cell. 2006 Jul 14;126(1):27-9. doi: 10.1016/j.cell.2006.06.030. Cell. 2006. PMID: 16839872 Review.
Similar articles
-
A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis.Cell Death Differ. 2007 Jul;14(7):1275-84. doi: 10.1038/sj.cdd.4402145. Epub 2007 Apr 20. Cell Death Differ. 2007. PMID: 17464328 Review.
-
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock.Biochim Biophys Acta. 2012 Oct;1817(10):1886-93. doi: 10.1016/j.bbabio.2012.05.001. Epub 2012 May 8. Biochim Biophys Acta. 2012. PMID: 22579715 Free PMC article.
-
OPA1 and PARL keep a lid on apoptosis.Cell. 2006 Jul 14;126(1):27-9. doi: 10.1016/j.cell.2006.06.030. Cell. 2006. PMID: 16839872 Review.
-
Multiple functions of mitochondria-shaping proteins.Novartis Found Symp. 2007;287:47-55; discussion 55-9. doi: 10.1002/9780470725207.ch4. Novartis Found Symp. 2007. PMID: 18074630 Review.
-
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.Cell. 2006 Jul 14;126(1):177-89. doi: 10.1016/j.cell.2006.06.025. Cell. 2006. PMID: 16839885
Cited by
-
Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.PLoS One. 2015 Jun 23;10(6):e0129667. doi: 10.1371/journal.pone.0129667. eCollection 2015. PLoS One. 2015. PMID: 26102349 Free PMC article.
-
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response.Front Cell Dev Biol. 2021 Mar 25;9:626117. doi: 10.3389/fcell.2021.626117. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33842456 Free PMC article. Review.
-
Mitochondrial Quality Control Proteases in Neuronal Welfare.J Neuroimmune Pharmacol. 2016 Dec;11(4):629-644. doi: 10.1007/s11481-016-9683-8. Epub 2016 May 2. J Neuroimmune Pharmacol. 2016. PMID: 27137937 Free PMC article. Review.
-
Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology.Kidney Int. 2013 Apr;83(4):568-81. doi: 10.1038/ki.2012.441. Epub 2013 Jan 16. Kidney Int. 2013. PMID: 23325082 Free PMC article. Review.
-
PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon.Sci Rep. 2016 Apr 7;6:24156. doi: 10.1038/srep24156. Sci Rep. 2016. PMID: 27052737 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
