Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis
- PMID: 16797878
- DOI: 10.1016/j.gene.2006.04.028
Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis
Abstract
Growth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair.
Similar articles
-
Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2.Circ Res. 2004 Feb 20;94(3):316-23. doi: 10.1161/01.RES.0000112965.70691.AC. Epub 2003 Dec 18. Circ Res. 2004. PMID: 14684627
-
The osteoblast-heparan sulfate axis: control of the bone cell lineage.Int J Biochem Cell Biol. 2005 Sep;37(9):1739-45. doi: 10.1016/j.biocel.2005.03.006. Epub 2005 Apr 26. Int J Biochem Cell Biol. 2005. PMID: 15886047 Review.
-
FGFs, heparan sulfate and FGFRs: complex interactions essential for development.Bioessays. 2000 Feb;22(2):108-12. doi: 10.1002/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M. Bioessays. 2000. PMID: 10655030 Review.
-
Insights into the role of heparan sulphate in fibroblast growth factor signalling.Biochem Soc Trans. 2006 Jun;34(Pt 3):442-5. doi: 10.1042/BST0340442. Biochem Soc Trans. 2006. PMID: 16709182 Review.
-
Potential mechanisms for the regulation of growth factor binding by heparin.J Theor Biol. 2000 Jul 21;205(2):215-30. doi: 10.1006/jtbi.2000.2064. J Theor Biol. 2000. PMID: 10873433
Cited by
-
Receptor tyrosine kinases: biological functions and anticancer targeted therapy.MedComm (2020). 2023 Dec 7;4(6):e446. doi: 10.1002/mco2.446. eCollection 2023 Dec. MedComm (2020). 2023. PMID: 38077251 Free PMC article. Review.
-
Stem cell secretome restore the adipo-osteo differentiation imbalance in diabetic dental pulp-derived mesenchymal stem cells.Chronic Dis Transl Med. 2024 May 6;10(4):340-349. doi: 10.1002/cdt3.125. eCollection 2024 Dec. Chronic Dis Transl Med. 2024. PMID: 39429485 Free PMC article.
-
Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration.Periodontol 2000. 2024 Feb;94(1):510-531. doi: 10.1111/prd.12515. Epub 2023 Aug 24. Periodontol 2000. 2024. PMID: 37614159 Review.
-
Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation.Blood. 2009 Sep 10;114(11):2333-43. doi: 10.1182/blood-2008-10-183459. Epub 2009 May 11. Blood. 2009. PMID: 19433859 Free PMC article.
-
The role of Ca2+ /Calcineurin/NFAT signalling pathway in osteoblastogenesis.Cell Prolif. 2021 Nov;54(11):e13122. doi: 10.1111/cpr.13122. Epub 2021 Sep 15. Cell Prolif. 2021. PMID: 34523757 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
