doi: 10.1007/s10529-006-9060-4.
Epub 2006 Jun 23.
Fungicidal and cytotoxic activity of a Capsicum chinense defensin expressed by endothelial cells
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- PMID: 16794772
- DOI: 10.1007/s10529-006-9060-4
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Fungicidal and cytotoxic activity of a Capsicum chinense defensin expressed by endothelial cells
Biotechnol Lett.
2006 Jul.
Abstract
Plant defensins are antimicrobial peptides that exhibit mainly antifungal activity against a broad range of plant fungal pathogens. However, their actions against Candida albicans have not been extensively studied. The mRNA for gamma-thionin, a defensin from Capsicum chinense, has been expressed in bovine endothelial cells. The conditioned medium of these cells showed antifungal activity on germ tube formation (60-70% of inhibition) and on the viability of C. albicans (70-80% of inhibition). Additionally, C. albicans was not able to penetrate transfected cells. Conditioned medium from these cells also inhibited the viability (80%) of the human tumor cell line, HeLa.
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