Review
doi: 10.1016/j.tcb.2006.05.003.
Epub 2006 Jun 21.
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
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- PMID: 16793271
- DOI: 10.1016/j.tcb.2006.05.003
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Review
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
Trends Cell Biol.
2006 Jul.
Abstract
Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.
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