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. 2007;56(3):331-339.
doi: 10.33549/physiolres.930944. Epub 2006 Jun 22.

The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen

G Jovcić  1 , D Bugarski, A Krstić, M Vlaski, M Petakov, S Mojsilović, N Stojanović, P Milenković
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Free article

The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen

G Jovcić et al. Physiol Res. 2007.
Free article

Abstract

To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs.

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