Synaptic amplifier of inflammatory pain in the spinal dorsal horn
- PMID: 16778058
- DOI: 10.1126/science.1127233
Synaptic amplifier of inflammatory pain in the spinal dorsal horn
Abstract
Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord. The synaptic hypothesis of hyperalgesia, which postulates that hyperalgesia is induced by the activity-dependent long-term potentiation (LTP) in the spinal cord, has been challenged, because in previous studies of pain pathways, LTP was experimentally induced by nerve stimulation at high frequencies ( approximately 100 hertz). This does not, however, resemble the real low-frequency afferent barrage that occurs during inflammation. We identified a synaptic amplifier at the origin of an ascending pain pathway that is switched-on by low-level activity in nociceptive nerve fibers. This model integrates known signal transduction pathways of hyperalgesia without contradiction.
Similar articles
-
Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice.Mol Pain. 2010 Jan 20;6:1. doi: 10.1186/1744-8069-6-1. Mol Pain. 2010. PMID: 20089138 Free PMC article.
-
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia.Science. 2003 Feb 21;299(5610):1237-40. doi: 10.1126/science.1080659. Science. 2003. PMID: 12595694
-
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.Science. 2009 Aug 7;325(5941):760-4. doi: 10.1126/science.1171870. Science. 2009. PMID: 19661434 Free PMC article.
-
The glycinergic control of spinal pain processing.Cell Mol Life Sci. 2005 Sep;62(18):2027-35. doi: 10.1007/s00018-005-5107-2. Cell Mol Life Sci. 2005. PMID: 15968463 Free PMC article. Review.
-
Ionotropic glutamate receptors and voltage-gated Ca²⁺ channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity.Neural Plast. 2013;2013:654257. doi: 10.1155/2013/654257. Epub 2013 Oct 2. Neural Plast. 2013. PMID: 24224102 Free PMC article. Review.
Cited by
-
Epigenetic mechanisms of chronic pain.Trends Neurosci. 2015 Apr;38(4):237-46. doi: 10.1016/j.tins.2015.02.001. Epub 2015 Mar 9. Trends Neurosci. 2015. PMID: 25765319 Free PMC article. Review.
-
Aberrant synaptic integration in adult lamina I projection neurons following neonatal tissue damage.J Neurosci. 2015 Feb 11;35(6):2438-51. doi: 10.1523/JNEUROSCI.3585-14.2015. J Neurosci. 2015. PMID: 25673839 Free PMC article.
-
Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action.Curr Pain Headache Rep. 2012 Jun;16(3):217-25. doi: 10.1007/s11916-012-0260-4. Curr Pain Headache Rep. 2012. PMID: 22399391 Review.
-
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn.J Physiol. 2007 May 1;580(Pt.3):883-94. doi: 10.1113/jphysiol.2006.125880. Epub 2007 Feb 15. J Physiol. 2007. PMID: 17303639 Free PMC article.
-
Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input.Neuroscience. 2010 Jun 2;167(4):1192-204. doi: 10.1016/j.neuroscience.2010.03.028. Epub 2010 Mar 18. Neuroscience. 2010. PMID: 20303396 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
