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. 2006:325:139-48.
doi: 10.1385/1-59745-005-7:139.

Observing S-phase dynamics of histone modifications with fluorescently labeled antibodies

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Observing S-phase dynamics of histone modifications with fluorescently labeled antibodies

Rong Wu et al. Methods Mol Biol. 2006.

Abstract

Histone modifications are central to epigenetic regulation and must be reestablished with each round of DNA replication. Here we describe methods to localize these modifications within mammalian nuclei and to relate them to specific spatiotemporal patterns of DNA replication.

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