The flavonoid ellagic acid from a medicinal herb inhibits host immune tolerance induced by the hepatitis B virus-e antigen
- PMID: 16720052
- DOI: 10.1016/j.antiviral.2006.04.006
The flavonoid ellagic acid from a medicinal herb inhibits host immune tolerance induced by the hepatitis B virus-e antigen
Abstract
The aim of this study is to characterize the role of ellagic acid, a flavonoid from a medicinal herb which blocks HBeAg secretion in a HBV infected cell line and in HBeAg transgenic mice, in immune tolerance in chronic HBV infection. Using the mouse strain C57ML/6, HBeAg-producing transgenic mice (HBeAg-Tg), under the control of metal ion-inducible promoter were generated. The effect on immune tolerance of HBeAg-Tg and the release of immune tolerance by the inhibitor of HBeAg secretion, ellagic acid, was tested using T/B cell proliferation, HBeAg/HBeAb production, cytotoxic T-lymphocyte (CTL) and cytokine assays. C57ML/6 based HBeAg-producing HBeAg-Tg mice were tolerant to HBeAg at the T and B-cell level, did not produce antibodies to HBeAg in vivo and in vitro, produced minimal levels of cytokines (IL-4 and IFN-gamma) and decreased CTL responses, while feeding mice with ellagic acid (5mg/kg body weight) blocked the immune tolerance caused by HBeAg. Our results suggest that host immune tolerance induced by HBeAg during HBV infection, a viral strategy to guarantee HBV infection, can be overcome by ellagic acid, thus it can be used as a therapeutic for HBV-carriers.
Similar articles
-
H-2(d) mice born to and reared by HBeAg-transgenic mothers do not develop T cell tolerance toward the hepatitis B virus core gene products.Virology. 2000 Jul 20;273(1):149-59. doi: 10.1006/viro.2000.0391. Virology. 2000. PMID: 10891417
-
A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes.Antiviral Res. 2005 Sep;67(3):163-8. doi: 10.1016/j.antiviral.2005.06.005. Antiviral Res. 2005. PMID: 16118024
-
Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice.J Immunol. 1994 Jan 15;152(2):455-66. J Immunol. 1994. PMID: 8283030
-
Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection.Hepatology. 2003 Nov;38(5):1075-86. doi: 10.1053/jhep.2003.50453. Hepatology. 2003. PMID: 14578844 Review.
-
Hepatitis B virus immunopathogenesis.Annu Rev Immunol. 1995;13:29-60. doi: 10.1146/annurev.iy.13.040195.000333. Annu Rev Immunol. 1995. PMID: 7612225 Review.
Cited by
-
IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4(+)CXCR5(+) TFH Cells.J Interferon Cytokine Res. 2015 Jun;35(6):454-63. doi: 10.1089/jir.2013.0122. Epub 2015 Feb 25. J Interferon Cytokine Res. 2015. PMID: 25714983 Free PMC article.
-
A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma.Front Pharmacol. 2024 Aug 9;15:1443667. doi: 10.3389/fphar.2024.1443667. eCollection 2024. Front Pharmacol. 2024. PMID: 39185304 Free PMC article. Review.
-
[Generation of a novel HBeAg transgenic mice using CRISPR/Cas9 technique].Nan Fang Yi Ke Da Xue Xue Bao. 2019 Sep 30;39(9):1017-1022. doi: 10.12122/j.issn.1673-4254.2019.09.03. Nan Fang Yi Ke Da Xue Xue Bao. 2019. PMID: 31640958 Free PMC article. Chinese.
-
Metabolites from traditional Chinese botanical drugs with anti-hepatitis B virus activity - a review.Front Pharmacol. 2024 Jul 12;15:1331967. doi: 10.3389/fphar.2024.1331967. eCollection 2024. Front Pharmacol. 2024. PMID: 39070799 Free PMC article. Review.
-
Research progress on the anticarcinogenic actions and mechanisms of ellagic acid.Cancer Biol Med. 2014 Jun;11(2):92-100. doi: 10.7497/j.issn.2095-3941.2014.02.004. Cancer Biol Med. 2014. PMID: 25009751 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
